Evidence map›Paper›PMID 40016681›Full record

Observational studyBMC public health2025

Potentially disabling factors of newly diagnosed leprosy patients in southwest China: a retrospective observational study.

Longchong Qiao, Mengyan Zhang, Haiqin Jiang, Ying Shi, Wenyue Zhang, Youming Mei, Meiwen Yu, Hongsheng Wang

Abstract readObservational Study
In one paragraph

Observational study in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Longchong Qiao *School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Mengyan Zhang *School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Haiqin JiangSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Ying ShiHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Wenyue ZhangHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Youming MeiHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Meiwen YuHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China. yumeiwen@163.com.
Hongsheng WangSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. whs33@vip.sina.com.

Funding

National Natural Science Foundation of China 81972950National Natural Science Foundation of China 82103748
6 · The paper itself

Abstract

backgroundWith the prevalence of leprosy dramatically declining, the focus of leprosy control has gradually shifted from the implementation of multidrug therapy (MDT) to accelerating the reduction of the disease burden and preventing disability. Southwestern China currently bears the highest leprosy burden in China and more than half of the disability cases reported every year are from this region. However, the potential risk factors of leprosy disability in this area remain unknown.

methodsIn this study, we evaluated the physical disabilities of 4578 leprosy patients in southwest China from 2010 to 2020. Clinical and epidemiological factors associated with physical disability resulting from leprosy were identified using multinomial logistic regression.

resultsA total of 4578 leprosy cases with complete information were reported in southwestern China during the 11 years. Among them, 1126 (24.60%) patients were diagnosed with grade 2 disability (G2D), and 737 (16.10%) were confirmed with grade 1 disability (G1D) at diagnosis. The potential factors associated with G2D are as follows: nerve damage, male, leprosy reaction, older age of the patient, the longer delay in diagnosis, and more skin lesions. Furthermore, nerve damage, leprosy reaction, male, older age, and longer delayed diagnosis were the main risk factors of G1D. Among them, nerve damage, older age, longer delayed diagnosis, male, and leprosy reaction were the common risk factors for G1D and G2D.

conclusionIn our study, we found older age, longer delayed diagnosis, male, more skin lesions, more nerve lesions, and leprosy reactions were associated with leprosy disability. These findings provide a foundation for the development of targeted interventions aimed at the early identification of individuals at higher risk of physical disability, as well as for self-care and health education to promote timely medical consultation to prevent leprosy-related disabilities.

Indexed as

LeprosyPersons with DisabilitiesAdolescentAdultAgedChildChinaFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsYoung AdultLeprosyMultinomial logistic regression analysisPhysical disability

Identifiers

PMID40016681
PMCPMC11869736

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.