Evidence map›Paper›PMID 40016540›Full record

ArticleActa neurologica Belgica2025

Expression levels of protein inhibitor of activated STAT (PIAS) family genes in Parkinson's disease patients: results from a case-control study.

Fariba Akbari Gavabari, Mohsen Rastegari-Pouyani, Saeid Afshar, Mehrdokht Mazdeh, Armin Bahramian, Siamak Shahidi, Elahe Talebi-Ghane, Mahsa Chalabi, Mohammad Mahdi Eftekharian

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Article in Acta neurologica Belgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Fariba Akbari GavabariDepartment of Immunology, School of Medicine, Hamadan University of Medical Sciences, Fahmideh Blvd, Hamadan, Iran.
Mohsen Rastegari-PouyaniDepartment of Immunology, School of Medicine, Hamadan University of Medical Sciences, Fahmideh Blvd, Hamadan, Iran.
Saeid AfsharCancer Research Center, Institute of Cancer, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran.
Mehrdokht MazdehDepartment of Neurology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Armin BahramianDepartment of Immunology, School of Medicine, Hamadan University of Medical Sciences, Fahmideh Blvd, Hamadan, Iran.
Siamak ShahidiNeurophysiology Research Center, Institute of Neuroscience and Mental Health, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran.
Elahe Talebi-GhaneModeling of Noncommunicable Diseases Research Center, Institute of Health Sciences and Technologies, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran.
Mahsa ChalabiDepartment of Immunology, School of Medicine, Hamadan University of Medical Sciences, Fahmideh Blvd, Hamadan, Iran.
Mohammad Mahdi EftekharianDepartment of Immunology, School of Medicine, Hamadan University of Medical Sciences, Fahmideh Blvd, Hamadan, Iran. eftekharian@umsha.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParkinson's disease (PD) is one of the most common progressive neurological disorders characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. In recent years, PIAS family proteins have been proposed as key factors in the development of neurodegenerative diseases. The aim of this study was to investigate the expression levels of PIAS family genes in patients with PD and compare them with those in the healthy control group.

methodsThe expression of PIAS family genes in the peripheral blood cells was investigated by RT-qPCR technique and the results were statistically analyzed using R software.

resultsPIAS4 gene expression was significantly lower in PD patients compared to the control group (p = 0.016), while we found no significant change in the expression of other PIAS genes between PD patients and healthy control group. Considering gender, the expression of PIAS3 was higher in males than that in females (p = 0.024). Also, significant downregulations in PIAS3 and PIAS4 genes were observed with increasing age, especially in men regardless of being patient or healthy (p = 0.04 and 0.001, respectively). In the correlation analysis, there were significant positive pairwise correlations between PIAS family members. Also, significant negative correlations between the expression of PIAS3 and PIAS4 genes with age were found.

conclusionThese findings show that part of the disruption of immune system regulation occurring in PD is probably related to the expression of PIAS family genes and that these proteins, especially PIAS4, can play an important role in the inflammatory and pathophysiological mechanisms of PD.

Indexed as

Parkinson DiseaseProtein Inhibitors of Activated STATAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedMolecular ChaperonesPoly-ADP-Ribose Binding ProteinsMolecular ChaperonesPIAS3 protein, humanPIAS4 protein, humanPoly-ADP-Ribose Binding ProteinsProtein Inhibitors of Activated STATInflammationNeurodegenerative diseasesParkinson's diseasePIAS

Identifiers

PMID40016540

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