Evidence map›Paper›PMID 40016539›Full record

ArticleMikrochimica acta2025

Development of a syringe-hosted load-and-read immunoassay device using autoinjected distance readout in paper inserts.

Haojie Li, Jie Liu, Cuili Li, Runze Wang, Sapna Kannan, XiuJun Li, Guanglei Fu

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haojie LiSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong ,Yantai University, Yantai, Shandong, 264005, China.
Jie LiuDepartment of Clinical Laboratory, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, 264000, China.
Cuili LiSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong ,Yantai University, Yantai, Shandong, 264005, China.
Runze WangSchool of Electromechanical and Automotive Engineering, Yantai University, Yantai, Shandong, 264005, China.
Sapna KannanDepartment of Chemistry and Biochemistry, Border Biomedical Research Center, Forensic Science, & Environmental Science and Engineering, University of Texas at El Paso, El Paso, TX, 79968, USA.
XiuJun LiDepartment of Chemistry and Biochemistry, Border Biomedical Research Center, Forensic Science, & Environmental Science and Engineering, University of Texas at El Paso, El Paso, TX, 79968, USA. xli4@utep.edu.
Guanglei FuSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong ,Yantai University, Yantai, Shandong, 264005, China. fuguanglei@ytu.edu.cn.

Funding

Point-of-care microdevices for simultaneous detection of multiple pertussis-like respiratory diseases from Bordetella speciesR41AI162477 · NIAID · MICROBIOCHIP DIAGNOSTICS LLC · PI LI, XIUJUN · 2022 to 2023
$391k
Cancer Prevention and Research Institute of Texas CPRIT; RP210165Natural Science Foundation of Shandong Province ZR2024MH055Research Starting Foundation of Yantai University 2222006U.S. NIH/NIAID R41AI162477U.S. NSF IIP2122712 and CHE2216473
6 · The paper itself

Abstract

Pressure-based signal readout is promising for developing instrument-free immunoassays, but new detection methods are desirable to further advance the applicability of point-of-care testing (POCT). Herein, we developed a syringe-hosted load-and-read immunoassay device using autoinjected distance readout in paper inserts. The device was composed of multiple disposable syringes as the host for immuno-recognition, a three-dimensional (3D)-printed loading magazine of the syringes, and paper inserts to the magazine for distance signal readout. Using prostate-specific antigen (PSA) as a model target, the immuno-recognition system was constructed on the inner cylinder walls of the syringes. The immuno-captured platinum nanoparticles (Pt NPs) catalyzed the decomposition of H

Indexed as

PaperProstate-Specific AntigenSyringesEquipment DesignHumansHydrogen PeroxideImmunoassayLimit of DetectionMetal NanoparticlesPlatinumHydrogen PeroxidePlatinumProstate-Specific AntigenImmunoassaysPaper devicesPoint-of-care testingPressure-based detection

Identifiers

PMID40016539

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.