Assessment of Rhinovirus Infection in a Mouse Model of COPD.

Krist H Antunes, Millie M Jackson, Kyle T Mincham, Robert J Snelgrove, Aran Singanayagam

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Krist H AntunesLaboratory of Clinical and Experimental Immunology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.

Millie M JacksonDepartment of Infectious Disease, Imperial College London, London, UK.

Kyle T MinchamNational Heart and Lung Institute, Imperial College London, London, UK.

Robert J SnelgroveNational Heart and Lung Institute, Imperial College London, London, UK.

Aran SinganayagamDepartment of Infectious Disease, Imperial College London, London, UK. a.singanayagam@imperial.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A better understanding of the mechanisms governing virus-induced exacerbations of chronic obstructive pulmonary disease (COPD) is urgently needed to develop more effective therapeutic approaches. Animal models are invaluable tools for gaining mechanistic insight into innate immunity. Here, we describe the methods required to establish a short-term mouse model comprising elastase administration to induce features of COPD, combined with infection using the minor group rhinovirus serotype A1 (RV-A1). This model recapitulates the hallmark features of human virus-induced COPD exacerbation and facilitates the study of mechanisms that drive these episodes.

Indexed as

Picornaviridae InfectionsPulmonary Disease, Chronic ObstructiveRhinovirusAnimalsDisease Models, AnimalHumansLungMiceBronchoalveolar lavageChronic obstructive pulmonary diseaseElastaseEmphysemaInflammationInnate immunity

Identifiers

PMID40016465

DOI10.1038/s41467-018-04574-1

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.