Evidence map›Paper›PMID 40016462›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Investigation of Differentiated Nasal Epithelial Responses to Infection with Clinical Isolates of Rhinovirus A and C.

Rebecca L Watkinson, Yury A Bochkov, James E Gern, Thomas Iosifidis, Kevin Looi, Ingrid A Laing, Anthony Kicic

Abstract read
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Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rebecca L WatkinsonDivision of Paediatrics, School of Medicine, The University of Western Australia, Crawley, WA, Australia.
Yury A BochkovDepartment of Paediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
James E GernDepartment of Paediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Thomas IosifidisDivision of Paediatrics, School of Medicine, The University of Western Australia, Crawley, WA, Australia.
Kevin LooiDivision of Paediatrics, School of Medicine, The University of Western Australia, Crawley, WA, Australia.
Ingrid A LaingDivision of Paediatrics, School of Medicine, The University of Western Australia, Crawley, WA, Australia.
Anthony KicicWal-Yan Respiratory Research Centre, The Kids Research Institute Australia, Nedlands, WA, Australia. Anthony.Kicic@thekids.org.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nasal epithelium is the primary point of contact for inhaled respiratory viruses such as rhinovirus, respiratory syncytial virus, influenza, and coronavirus, among others. In order to establish infection, these viruses must engage their respective receptors located on host epithelial cells and begin replication. However, the nasal epithelium is also a pivotal orchestrator of both structural and innate immune defenses against these pathogens and thus mounts a broad antiviral response to halt the progression of the infection into the lower airways. Of note, the most common virus found in the airways of children presenting to the hospital emergency department with acute wheezing and asthma is rhinovirus C (RV-C), followed by rhinovirus A (RV-A). Here, we illustrate infection of a preclinical differentiated nasal epithelial model with clinical isolates of RV-A and -C, in conjunction with several methods utilized for characterization of epithelial responses post-infection in vitro.

Indexed as

Nasal MucosaPicornaviridae InfectionsRhinovirusCell DifferentiationCell LineEnterovirusEpithelial CellsHumansAsthmaConfocal microscopyCytokinesEpithelial barrierNasal epitheliumPediatricsReceptorsRhinovirusViral infectionWheeze

Identifiers

PMID40016462

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.