Evidence map›Paper›PMID 40016417›Full record

ArticleThe EMBO journal2025

An epitranscriptomic program maintains skeletal stem cell quiescence via a METTL3-FEM1B-GLI1 axis.

Jing Wang, Weidong Liu, Tiantian Zhang, Manman Cui, Kexin Gao, Pengbo Lu, Shuxin Yao, Ziyan Cao, Yanbing Zheng, Wen Tian and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jing Wang *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.ORCID http://orcid.org/0000-0003-1683-2082
Weidong Liu *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Tiantian ZhangFrontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Manman CuiFrontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Kexin GaoFrontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Pengbo LuFrontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Shuxin YaoFrontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Ziyan CaoFrontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Yanbing ZhengFrontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Wen TianFrontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Yan LiFrontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Rong YinFrontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Jin HuFrontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Guoqiang HanFrontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.ORCID http://orcid.org/0009-0000-2477-0593
Jianfei LiangKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, 710004, Xi'an, China.ORCID http://orcid.org/0000-0001-6468-4817
Fuling ZhouDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Jihua ChaiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China. cjh@whu.edu.cn.ORCID http://orcid.org/0009-0005-6637-3672
Haojian ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China. haojian_zhang@whu.edu.cn.ORCID http://orcid.org/0000-0002-9394-9383

Funding

China Postdoctoral Science Foundation (China Postdoctoral Foundation Project) 2022TQ0238MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities) 2042021kf0225MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities) 2042022dx0003MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities) 2042024kf1022MOST | National Key Research and Development Program of China Stem Cell and Translational Research (Stem Cell and Translational Research) 2022YFA0103200MOST | National Natural Science Foundation of China (NSFC) 82200188MOST | National Natural Science Foundation of China (NSFC) 82230007MOST | National Natural Science Foundation of China (NSFC) 82325003MOST | National Natural Science Foundation of China (NSFC) 82401137
6 · The paper itself

Abstract

Skeletal stem cells (SSCs) maintain the skeletal system via pluripotency and differentiation capacity. However, it remains largely unknown how these cells precisely regulate their function to maintain skeletal organization. Here, we delineate the RNA m

Indexed as

Cell Cycle ProteinsEpigenesis, GeneticMethyltransferasesStem CellsTranscriptomeZinc Finger Protein GLI1AnimalsCell DifferentiationMiceMice, KnockoutSignal TransductionCell Cycle ProteinsGli1 protein, mouseMethyltransferasesMettl3 protein, mouseZinc Finger Protein GLI1FEM1BProteostasisQuiescenceRNA m6ASkeletal Stem Cell

Identifiers

PMID40016417
PMCPMC12000498

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.