Evidence map›Paper›PMID 40016385›Full record

ArticleScientific reports2025

The calcineurin-responsive transcription factor Crz1 regulates the expression of CMK2 via a sole CDRE site in its promoter in budding yeast.

Linghuo Jiang, Yiying Gu, Yongqiang Jiang, Liudan Wei, Lijun Meng, Ni Guan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Linghuo JiangLaboratory of Yeast Biology and Ethanol Fermentation Technology, State Key Laboratory of Non-Food Biomass Energy Technology, Institute of Biological Sciences and Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, Nanning, 530007, Guangxi, China. linghuojiang@hotmail.com.
Yiying GuLaboratory of Yeast Biology and Ethanol Fermentation Technology, State Key Laboratory of Non-Food Biomass Energy Technology, Institute of Biological Sciences and Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, Nanning, 530007, Guangxi, China.
Yongqiang JiangInstitute of Biology, Guangxi Academy of Sciences, Nanning, 530007, Guangxi, China.
Liudan WeiLaboratory of Yeast Biology and Ethanol Fermentation Technology, State Key Laboratory of Non-Food Biomass Energy Technology, Institute of Biological Sciences and Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, Nanning, 530007, Guangxi, China.
Lijun MengLaboratory of Yeast Biology and Ethanol Fermentation Technology, State Key Laboratory of Non-Food Biomass Energy Technology, Institute of Biological Sciences and Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, Nanning, 530007, Guangxi, China.
Ni GuanLaboratory of Yeast Biology and Ethanol Fermentation Technology, State Key Laboratory of Non-Food Biomass Energy Technology, Institute of Biological Sciences and Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, Nanning, 530007, Guangxi, China.

Funding

Guangxi Innovation-Driven Development Major Science and Technology Innovation Base Construction Project 2022-36-Z06Guangxi Science and Technology Base and Talent Special project 2021AC18023Guangxi Science and Technology Base and Talent Special project AD23023007
6 · The paper itself

Abstract

As a yeast homolog of mammalian calcium/calmodulin-dependent protein kinase II (CaMKII), Cmk2 functions as a negative regulator of calcium signaling in Saccharomyces cerevisiae. We show here that the transcription expression of CMK2 is controlled mainly by the transcription factor Crz1 and also by other factor(s) in response to calcium stress. There are four potential binding sites (calcium/calcineurin-dependent responsive elements; CDREs) for Crz1 in the promoter of CMK2. Through mutational analysis, we demonstrated that mutation of only the site (5' G

Indexed as

CalcineurinDNA-Binding ProteinsGene Expression Regulation, FungalPromoter Regions, GeneticResponse ElementsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsBinding SitesCalciumProtein BindingCalcineurinCalciumCRZ1 protein, S cerevisiaeDNA-Binding ProteinsSaccharomyces cerevisiae ProteinsTranscription FactorsCalciumCmk2Crz1ExpressionPromoterSaccharomyces cerevisiae

Identifiers

PMID40016385
PMCPMC11868491

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.