Evidence map›Paper›PMID 40016321›Full record

ArticleScientific reports2025

Unique formation of organic glass from a human brain in the Vesuvius eruption of 79 CE.

Guido Giordano, Alessandra Pensa, Alessandro Vona, Danilo Di Genova, Raschid Al-Mukadam, Claudia Romano, Joachim Deubener, Alessandro Frontoni, PierPaolo Petrone

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Guido GiordanoDipartimento di Scienze, Università Roma Tre, Largo San Leonardo Murialdo 1, Roma, 00146, Italy. guido.giordano@uniroma3.it.
Alessandra PensaDipartimento di Scienze, Università Roma Tre, Largo San Leonardo Murialdo 1, Roma, 00146, Italy.
Alessandro VonaDipartimento di Scienze, Università Roma Tre, Largo San Leonardo Murialdo 1, Roma, 00146, Italy.
Danilo Di GenovaTechnische Universität Clausthal, Adolph-Roemer-Straße 2A, 38678, Clausthal-Zellerfeld, Germany.
Raschid Al-MukadamTechnische Universität Clausthal, Adolph-Roemer-Straße 2A, 38678, Clausthal-Zellerfeld, Germany.
Claudia RomanoDipartimento di Scienze, Università Roma Tre, Largo San Leonardo Murialdo 1, Roma, 00146, Italy.
Joachim DeubenerTechnische Universität Clausthal, Adolph-Roemer-Straße 2A, 38678, Clausthal-Zellerfeld, Germany.
Alessandro FrontoniDipartimento di Scienze, Università Roma Tre, Largo San Leonardo Murialdo 1, Roma, 00146, Italy.
PierPaolo PetroneDipartimento di Scienze Biomediche Avanzate, Università di Napoli Federico II, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glass forms when a liquid is fast cooled preventing crystallization, across a reversible process known as the glass transition. Organic tissues are commonly preserved as glass by processes of vitrification at very low temperatures, known as cryopreservation, and can return to their original soft state when heated back to ambient temperature. It would therefore be impossible to find organic glass embedded in volcanic deposits that have reached several hundred of Celsius degrees. Here we demonstrate that material with glassy appearance found within the skull of a seemingly male human body entombed within the hot pyroclastic flow deposits of the 79 CE Vesuvius eruption formed by a unique process of vitrification of his brain at very high temperature, and is the only such occurrence on Earth. Calorimetric analyses show that the temperature at which the brain transformed into glass was well above 510 °C, implying that the body was exposed to the passage and vanishing of a short-lived, dilute and much hotter pyroclastic flow, explaining its early fast heating and the following very fast cooling. The glass that formed as a result of such a unique process attained a perfect state of preservation of the brain and its microstructures.

Indexed as

BrainGlassVolcanic EruptionsHumansMaleVitrification

Identifiers

PMID40016321
PMCPMC11868551

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.