Evidence map›Paper›PMID 40016131›Full record

SynthesisAJNR. American journal of neuroradiology2025

Initial Experience with the Pipeline Vantage Flow Diverter for Intracranial Aneurysms: A Systematic Review and Meta-Analysis.

Jonathan Cortese, Sherief Ghozy, Parya Valizadeh, Alireza Hasanzadeh, Melika Amoukhteh, Payam Jannatdoust, Amir Hassankhani, Ali Ahmadzade, Dan Adrian Popica, David F Kallmes and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jonathan CorteseFrom the Department of Radiology (J.C., S.G., P.V., A. Hasanzadeh, M.A., P.J., A. Hassankhani, A.A., D.F.K.), Mayo Clinic Rochester, Minnesota cortese.jonathan@mayo.edu.ORCID 0000-0002-1616-9113
Sherief GhozyFrom the Department of Radiology (J.C., S.G., P.V., A. Hasanzadeh, M.A., P.J., A. Hassankhani, A.A., D.F.K.), Mayo Clinic Rochester, Minnesota.ORCID 0000-0001-5629-3023
Parya ValizadehFrom the Department of Radiology (J.C., S.G., P.V., A. Hasanzadeh, M.A., P.J., A. Hassankhani, A.A., D.F.K.), Mayo Clinic Rochester, Minnesota.
Alireza HasanzadehFrom the Department of Radiology (J.C., S.G., P.V., A. Hasanzadeh, M.A., P.J., A. Hassankhani, A.A., D.F.K.), Mayo Clinic Rochester, Minnesota.ORCID 0000-0002-1041-6080
Melika AmoukhtehFrom the Department of Radiology (J.C., S.G., P.V., A. Hasanzadeh, M.A., P.J., A. Hassankhani, A.A., D.F.K.), Mayo Clinic Rochester, Minnesota.ORCID 0000-0003-3488-8960
Payam JannatdoustFrom the Department of Radiology (J.C., S.G., P.V., A. Hasanzadeh, M.A., P.J., A. Hassankhani, A.A., D.F.K.), Mayo Clinic Rochester, Minnesota.
Amir HassankhaniFrom the Department of Radiology (J.C., S.G., P.V., A. Hasanzadeh, M.A., P.J., A. Hassankhani, A.A., D.F.K.), Mayo Clinic Rochester, Minnesota.ORCID 0000-0002-0529-5341
Ali AhmadzadeFrom the Department of Radiology (J.C., S.G., P.V., A. Hasanzadeh, M.A., P.J., A. Hassankhani, A.A., D.F.K.), Mayo Clinic Rochester, Minnesota.ORCID 0000-0001-6182-4853
Dan Adrian PopicaDepartment of Interventional Neuroradiology (NEURI Vascular Center) (J.C., D.A.P.), Bicetre University-Hospital, Le Kremlin-Bicetre, France.ORCID 0000-0002-0948-0472
David F KallmesFrom the Department of Radiology (J.C., S.G., P.V., A. Hasanzadeh, M.A., P.J., A. Hassankhani, A.A., D.F.K.), Mayo Clinic Rochester, Minnesota.ORCID 0000-0002-8495-0040
Ramanathan KadirvelDepartment of Neurologic Surgery (S.G., R.K.), Mayo Clinic Rochester, Minnesota.ORCID 0000-0002-6786-9953

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Pipeline Vantage Flow diverter (Vantage) is the latest generation of Pipeline flow diverters introducing Cobalt-chronium drawn-filled tubing and 48 to 68 wires. PURPOSE: We report the initial safety and efficacy of Vantage in treating intracranial aneurysms in the published literature. DATA SOURCES: A systematic review and meta-analysis was conducted according to established protocols. Searches were conducted in PubMed, Scopus, Web-of-Science, and Embase databases up to December 2023. Original studies reporting treatment outcomes for intracranial aneurysms using Vantage in more than five patients were included. STUDY SELECTION: Pooled data from 5 studies (373 patients, 418 aneurysms) were analyzed. DATA ANALYSIS: Outcomes of interest were: technical success, occlusion rates, complication outcomes and mortality. DATA SYNTHESIS: A technical success rate of 99.2% (95% CI: 98.29%-100%) was found. In unruptured cases, success rate was 378/383 (99.6%) versus 17/20 (85.0%) in ruptured cases ( LIMITATIONS: Only five studies, some with small number of patients, were included in this meta-analysis which may limit the generalizability of our findings. The absence of long term follow-up also limits the assessment of treatment durability.

conclusionsIn this meta-analysis, we found that Vantage initial experience is similar to previous version of the Pipeline Embolization Device in terms of safety and efficacy for treatment of intracranial aneurysms, in particular unruptured aneurysms. Further prospective and comparative studies with patient outcome data specific to aneurysm location are needed to confirm the safety and efficacy of Vantage.

Indexed as

Embolization, TherapeuticEndovascular ProceduresIntracranial AneurysmStentsHumansTreatment Outcome

Identifiers

PMID40016131
PMCPMC11979821

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.