ArticleUltrasound in medicine & biology2025
Acoustic Cavitation Emissions Predict Near-complete/complete Histotripsy Treatment in Soft Tissues.
Article in Ultrasound in medicine & biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Quantification of Histotripsy Dosage Using Machine Learning-Enhanced Ultrasound Imaging Analysis: Correlation with Histological Outcomes.Academic radiology · 2026Article
- Focused ultrasound-induced cavitation in a human brain microphysiological system produces injury signaling biomarkers consistent with blast trauma.npj biomedical innovations · 2026Article
- Research progress on the antitumor immune regulation mechanisms and combined treatment strategies of histotripsy: A review.Medicine · 2026Review
- Histotripsy dose impacts tumor cellular damage and treatment outcomes in a preclinical model of hepatocellular carcinoma.Scientific reports · 2026Article
- MRI for the Assessment of Histotripsy Ablation in a Canine Osteosarcoma Comparative Oncology Model.Ultrasound in medicine & biology · 2026Article
- Quantum-edge synergy for dynamic acoustic compensation in ultrasound safety: a narrative review of tissue heterogeneity challenges.Frontiers in medical technology · 2026Review
- Histotripsy Dose Impacts Treated Tumor Immune Infiltration and Survival Outcomes in a Murine B16F10 Melanoma Model.Cancers · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveHistotripsy is a non-invasive acoustic ablation technique that leverages cavitation to impart mechanical damage to a viscoelastic medium, such as tissue. Although histotripsy bubbles and lesions can be imaged with a variety of modalities, reliable methods to predict tissue disruption across different tissue-types remain to be determined. APPROACH: Several ex-vivo bovine tissues were ablated by intrinsic threshold histotripsy over a range of pulse-per-location acoustic doses. Acoustic Cavitation Emission (ACE) signals were captured following every other therapeutic pulse using transmit-receive capable histotripsy arrays. Final bubble lifespan, lifespan-slope, and percent-reduction were calculated and correlated against histologic necrosis score (0-5: 0=0% necrosis, 5=>95% necrosis) and residual structure score (0-4: 0=none present, 4=intact) to evaluate the ability of features from ACE-signals to predict histotripsy-induced damage. Further, optimal ACE-feature thresholds were determined for binary evaluation of whether a necrosis score equal or greater than 4 had been reached.
resultsMeasured lifespans increased and lifespan-slopes decreased with pulses per location (ppl) and eventually plateaued in all tissue types, in similar trends to those previously observed in tissue phantoms. Necrosis score increased and residual structure decreased with increasing acoustic dose. Bubble lifespan-slope and percent-reduction correlated well with necrosis score. Thresholds able to predict the necrosis score of 4 or greater in brain, liver, and kidney were calculated with high sensitivity/specificity (>80%). The necrosis score of 4 and 5 is expected to correspond to near-complete/complete ablation by histological evaluation.
conclusionFeatures measured from ACE-signals, particularly the lifespan-slope and percent reduction, were used to predict near-complete/complete ablation of large-volume histotripsy treatments in ex vivo bovine liver, kidney, and brain tissues with good accuracy. Tissue heterogeneities were observed to impact the histotripsy damage and corresponding ACE-signals, and thus the predication accuracy.
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