Evidence map›Paper›PMID 40015918›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

MHC-I-Driven Antitumor Immunity Counterbalances Low Absorbed Doses of Radiopharmaceutical Therapy.

Julie Constanzo, Aliasghar Parach, Timothee David, Joshua Karam, Frank Bruchertseifer, Alfred Morgenstern, Marta Jarlier, Manuel Bardiès, Emmanuel Deshayes, Amelie Gudin-de-Vallerin and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04104529 (Establishment of a Clinico-biological Database in Patients Treated With Metabolic Radiotherapy in the Nuclear Medicine Department), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04104529 narecruitingnot on this map

Establishment of a Clinico-biological Database in Patients Treated With Metabolic Radiotherapy in the Nuclear Medicine Department

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2019 to 2026Enrolled350ConditionsThyroid Cancer, Prostate Cancer, Neuroendocrine TumorsArmsBiological collection, tumor collection
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Targeted Radionuclide Therapy: Current Landscape and Combination Approaches to Improve Oncology Outcomes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
  2. Review
  3. Review
  4. LiposomalCancer science · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Julie ConstanzoInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Nuclear Medicine Department, Institut régional du Cancer de Montpellier (ICM), Montpellier, France, and Équipe Labellisée Ligue Contre le Cancer, Paris, France; julie.constanzo@inserm.fr jean-pierre.pouget@inserm.fr.
Aliasghar ParachInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Nuclear Medicine Department, Institut régional du Cancer de Montpellier (ICM), Montpellier, France, and Équipe Labellisée Ligue Contre le Cancer, Paris, France.
Timothee DavidInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Nuclear Medicine Department, Institut régional du Cancer de Montpellier (ICM), Montpellier, France, and Équipe Labellisée Ligue Contre le Cancer, Paris, France.
Joshua KaramInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Nuclear Medicine Department, Institut régional du Cancer de Montpellier (ICM), Montpellier, France, and Équipe Labellisée Ligue Contre le Cancer, Paris, France.
Frank BruchertseiferJoint Research Centre, European Commission, Karlsruhe, Germany.
Alfred MorgensternJoint Research Centre, European Commission, Karlsruhe, Germany.
Marta JarlierBiometrics Unit, Institut Régional du Cancer Montpellier, Montpellier, France; and.
Manuel BardièsInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Nuclear Medicine Department, Institut régional du Cancer de Montpellier (ICM), Montpellier, France, and Équipe Labellisée Ligue Contre le Cancer, Paris, France.
Emmanuel DeshayesInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Nuclear Medicine Department, Institut régional du Cancer de Montpellier (ICM), Montpellier, France, and Équipe Labellisée Ligue Contre le Cancer, Paris, France.
Amelie Gudin-de-VallerinTranslational Research Unit, Institut Régional du Cancer Montpellier, Montpellier, France.
Florence Boissière-MichotTranslational Research Unit, Institut Régional du Cancer Montpellier, Montpellier, France.
Evelyne Lopez-CrapezTranslational Research Unit, Institut Régional du Cancer Montpellier, Montpellier, France.
Jean-Pierre PougetInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Nuclear Medicine Department, Institut régional du Cancer de Montpellier (ICM), Montpellier, France, and Équipe Labellisée Ligue Contre le Cancer, Paris, France; julie.constanzo@inserm.fr jean-pierre.pouget@inserm.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preclinical and clinical studies increasingly show that the immune response plays a major role in radiotherapy. Here, we investigated the role of major histocompatibility complex class I (MHC-I) molecules recognized by cytotoxic CD8

Indexed as

Histocompatibility Antigens Class IRadiopharmaceuticalsActiniumAnimalsAntibodies, MonoclonalCD8-Positive T-LymphocytesCell Line, TumorFemaleHumansMiceMice, Inbred C57BLMice, NudeActiniumActinium-225Antibodies, MonoclonalHistocompatibility Antigens Class IRadiopharmaceuticals225Acbystander immunitymicroenvironmentradioimmunotherapytargeted radionuclide therapyT-cell adaptive immunity

Identifiers

PMID40015918
PMCPMC12051770

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.