Evidence map›Paper›PMID 40015759›Full record

ArticleThe journal of prevention of Alzheimer's disease2025

American's overall and equity-based societal valuation of a disease-modifying Alzheimer's treatment: Results from a discrete choice experiment.

Francisco Perez-Arce, Jeremy Burke, Lila Rabinovich, Quanwu Zhang, Amir Abbas Tahami Monfared, Soeren Mattke

Abstract read
In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francisco Perez-ArceThe USC Brain Health Observatory, University of Southern California, Los Angeles, CA, USA.
Jeremy BurkeThe USC Brain Health Observatory, University of Southern California, Los Angeles, CA, USA.
Lila RabinovichThe USC Brain Health Observatory, University of Southern California, Los Angeles, CA, USA.
Quanwu ZhangEisai Inc., Nutley, NJ, USA.
Amir Abbas Tahami MonfaredEisai Inc., Nutley, NJ, USA; Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
Soeren MattkeThe USC Brain Health Observatory, University of Southern California, Los Angeles, CA, USA. Electronic address: mattke@usc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo estimate Americans' willingness-to-pay (WTP) for universal access to a disease-modifying Alzheimer's disease (AD) treatment with a discrete choice experiment in a nationally representative sample. As part of this experiment, we examined whether providing information about the higher disease burden among minorities and persons of lower socioeconomic status (SES) changes WTP.

methodsWe conducted an information experiment using the nationally representative Understanding America Study (UAS) panel. Participants were provided with general information about AD and a hypothetical treatment that reduces disease progression by 30 %. Two-thirds of the sample were randomized to receive additional information about the higher prevalence of Alzheimer's among either lower SES groups or racial/ethnic minorities. We measured participants' WTP for making the treatment nationally available as a fixed annual fee and income-proportionate fee. Differences in WTP between those exposed to the additional information and those who were not provide the societal valuation of the equity-enhancing effects of the AD treatment.

resultsAverage valuations were $252, $260 and $247 per year, and 0.59 %, 0.59 % and 0.61 % of earned income, for the control, race/ethnicity and SES frames, respectively-all statistically indistinguishable. These average results imply that Americans would be willing to pay $33.7 billion based on the fixed fee and $51.4 billion based on the income-related charge for universal access to an AD treatment annually, but their valuation does not further increase when informed about equity considerations.

conclusionsWhile Americans value universal access to an AD treatment highly, health equity considerations did not significantly alter respondents' WTP.

Indexed as

Alzheimer DiseaseChoice BehaviorHealth EquityHealth Services AccessibilityAgedFemaleHumansMaleMiddle AgedSocial ClassUnited StatesAlzheimer's diseaseDementiaDisease modifying treatmentEconomic evaluationHealth equityInformation experiment

Identifiers

PMID40015759
PMCPMC12183966

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.