Evidence map›Paper›PMID 40015653›Full record

ArticleNeurobiology of disease2025

Essential tremor disrupts rhythmic brain networks during naturalistic movement.

Timothy O West, Kenan Steidel, Tjalda Flessner, Alexander Calvano, Deniz Kucukahmetler, Mariëlle J Stam, Meaghan E Spedden, Benedikt Wahl, Veikko Jousmäki, John Eraifej and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. SPM-30 years and beyond.Cerebral cortex (New York, N.Y. : 1991) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Timothy O WestDepartment of Bioengineering, Sir Michael Uren Hub, Imperial College London, London W12 0BZ, UK; Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London WC1N 3AR, UK. Electronic address: t.west@imperial.ac.uk.
Kenan SteidelDepartment of Neurology, Philipps-University Marburg, 35041 Marburg, Germany.
Tjalda FlessnerDepartment of Neurology, Philipps-University Marburg, 35041 Marburg, Germany.
Alexander CalvanoDepartment of Neurology, Philipps-University Marburg, 35041 Marburg, Germany.
Deniz KucukahmetlerDepartment of Bioengineering, Sir Michael Uren Hub, Imperial College London, London W12 0BZ, UK.
Mariëlle J StamDepartment of Neurology, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, the Netherlands.
Meaghan E SpeddenDepartment of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London WC1N 3AR, UK.
Benedikt WahlFaculty of Electrical Engineering and Information Technology, RWTH Aachen University, 52062 Aachen, Germany.
Veikko JousmäkiAalto Neuroimaging, Aalto University, Espoo, Finland.
John EraifejMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
Ashwini OswalMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
Tabish A SaifeeDepartment of Neurology, National Hospital for Neurology & Neurosurgery, Queen Square, London WC1N 3BG, UK; Department of Clinical and Movement Neurosciences, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Gareth BarnesDepartment of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London WC1N 3AR, UK.
Simon F FarmerDepartment of Neurology, National Hospital for Neurology & Neurosurgery, Queen Square, London WC1N 3BG, UK; Department of Clinical and Movement Neurosciences, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
David J PedrosaDepartment of Neurology, Philipps-University Marburg, 35041 Marburg, Germany; Centre of Mind, Brain and Behaviour, Philipps-University Marburg, 35041 Marburg, Germany.
Hayriye CagnanDepartment of Bioengineering, Sir Michael Uren Hub, Imperial College London, London W12 0BZ, UK; Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London WC1N 3AR, UK.

Funding

Medical Research Council MR/R020418/1Medical Research Council MR/W024810/1Wellcome Trust 203147Wellcome Trust 204826
6 · The paper itself

Abstract

Essential Tremor (ET) is a very common neurological disorder characterised by involuntary rhythmic movements attributable to pathological synchronization within corticothalamic circuits. Previous work has focused on tremor in isolation, overlooking broader disturbances to motor control during naturalistic movements such as reaching. We hypothesised that ET disrupts the sequential engagement of large-scale rhythmic brain networks, leading to both tremor and deficits in motor planning and execution. To test this, we performed whole-head neuroimaging during an upper-limb reaching task using high-density electroencephalography in ET patients and healthy controls, alongside optically pumped magnetoencephalography in a smaller cohort. Key motor regions-including the supplementary motor area, premotor cortex, posterior parietal cortex, and motor cerebellum-were synchronized to tremor rhythms. Patients exhibited a 15 % increase in low beta (14-21 Hz) desynchronization over the supplementary motor area during movement, which strongly correlated with tremor severity (R

Indexed as

BrainEssential TremorNerve NetAdultAgedElectroencephalographyFemaleHumansMagnetoencephalographyMaleMiddle AgedMovementEssential tremorMotor controlMovement disordersOscillationsReaching

Identifiers

PMID40015653
PMCPMC7617547

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.