Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2026
Interoceptive Exposure Impacts Food-Cue Extinction in Adolescents With Low-Weight Eating Disorders: A Functional Magnetic Resonance Imaging Study.
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02795455 (Reward Systems and Food Avoidance in Adolescents With Low Weight Eating Disorders), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reward Systems and Food Avoidance in Adolescents With Low Weight Eating Disorders
Who cites it
2 citing papers in PubMed.
- Evidence of Altered Biobehavioral Threat Processes in Adolescents With Eating Disorders: A Scoping Review.The International journal of eating disorders · 2025Article
- The adamant adherence to a prior belief: the case of anosognosia in anorexia nervosa.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveThis randomized controlled study tested the effect of interoceptive exposure on anterior insula function and connectivity for the extinction of palatable and rotten food-cue associations in adolescent girls with low weight eating disorders (LWED).
methodA food-related conditioning paradigm was performed by 39 adolescent girls with LWED and 19 matched controls during functional magnetic resonance imaging (fMRI). Adolescents with LWED were then randomized to 6 sessions of either interoceptive exposure (n = 18) or family-based (n = 21) treatment, followed by a second functional magnetic resonance imaging scan. Whole-brain activation and insula-driven connectivity for the extinction of palatable and rotten food-cue associations were compared between groups, and changes over treatment were compared between the 2 therapies.
resultsAdolescents with LWED exhibited diminished bilateral anterior insula activation for the extinction of palatable food-cue associations compared with controls (t
conclusionThese results suggest that targeting food avoidance in adolescent girls with LWED using interoceptive exposure engages anterior insula regions that mediate the visceral sensation of disgust and may underlie the resistance to extinction. The findings present a window into possible pathophysiological mechanisms of anorexia nervosa and other LWED PLAIN LANGUAGE SUMMARY: This randomized controlled study tested the effect of interoceptive exposure, which aims to reduce conditioned disgust responses to food. This treatment was compared to family-based treatment and the focus was on changes in anterior insula function. 39 adolescent girls with low-weight eating disorders (LWED) and 19 matched controls underwent food-related conditioning during functional magnetic resonance imaging, followed by interoceptive exposure or family-based treatment and a post-intervention imaging session. Key results showed that brief interoceptive exposure treatment increased left anterior insula activation for the extinction of palatable food-cue associations. These results offer new insights into the role of disgust and possible triggers and pathways to anorexia nervosa and other LWED. CLINICAL TRIAL REGISTRATION INFORMATION: Reward Systems and Food Avoidance in Eating Disorders; https://clinicaltrials.gov/study/NCT02795455.
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