Evidence map›Paper›PMID 40014869›Full record

ArticleJournal of the American Chemical Society2025

Transition State Analysis of SAMHD1 from Primary

Ananda K Ghosh, Daniel P Groom, Vern L Schramm

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Transition-state analysis of the arginine-specific human ADP-ribosyltransferase 1.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ananda K GhoshDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.ORCID 0000-0002-5485-4760
Daniel P GroomDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.ORCID 0009-0004-9353-1851
Vern L SchrammDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.ORCID 0000-0002-8056-1929

Funding

TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONSR01GM041916 · NIGMS · YESHIVA UNIVERSITY · PI SCHRAMM, VERN L. · 1989 to 2023
$10.0M
Targeting the PNP - SAMHD1 synthetic-lethal combination in cancerR01CA290537 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Vern L. Schramm · 2024 to 2026
$1.8M
NCI NIH HHS R01 CA290537NIGMS NIH HHS R01 GM041916
6 · The paper itself

Abstract

Human sterile alpha motif and HD-domain-containing protein 1 (SAMHD1) is an allosterically regulated dNTP triphosphohydrolase (dNTP + H

Indexed as

Deoxyadenine NucleotidesSAM Domain and HD Domain-Containing Protein 1HumansHydrolysisKineticsOxygen IsotopesSolvents2'-deoxyadenosine triphosphateDeoxyadenine NucleotidesOxygen IsotopesSAM Domain and HD Domain-Containing Protein 1SAMHD1 protein, humanSolvents

Identifiers

PMID40014869
PMCPMC12990285

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.