ArticleScience (New York, N.Y.)2025
Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection.
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Regulatory T cell induction strategies and applications in the treatment of immune and non-immune diseases.Signal transduction and targeted therapy · 2026Review
- [A multi-level study of androgen deprivation therapy on the immune microenvironment in prostate cancer].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- TCR signal strength during positive selection shapes CD25 expression patterns on thymically derived regulatory T cells.bioRxiv : the preprint server for biology · 2026Article
- Potentiating mild photothermal therapy via CDK12/13-mediated AKT suppression to orchestrate ferroptosis-apoptosis crosstalk for vaccine-like immunity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- CNS1-dependent regulatory T cells shape recovery from acute lung injury.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age-Related Diseases.Immunological reviews · 2026Review
- Regulatory T cells restrain IL-15-mediated cytotoxic and bystander T cell activity in mucosal tissue without compromising antigen-driven memory.bioRxiv : the preprint server for biology · 2026Article
- Regulatory T Cell Heterogeneity in the Steady State and Tumor.Immune network · 2026Review
- Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity.Cell · 2026Article
- Research Progress of Molecular HDrug design, development and therapy · 2026Review
- The relativity of regulatory T cell suppression modes.Frontiers in immunology · 2026Review
- Peripheral blood biomarkers in PD-1/PD-L1 immunotherapy: distinguishing predictive from prognostic biomarkers.Frontiers in immunology · 2026Review
- Foreign epitope-specific regulatory T cells respond robustly to vaccination and limit Th1 differentiation by conventional T cells specific for the same epitope.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Functional Specialization and Collaboration of cDC2 Subsets in CD4+ T Cell Priming and Differentiation.Immunological reviews · 2025Review
- TNature immunology · 2025Article
- The role of IL-2 in type 2 immunity.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
David E J Klawon *Department of Pathology, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-7953-2525
Nicole Pagane *The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.ORCID 0009-0007-0079-0515
Matthew T WalkerDepartment of Pathology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-0921-5812
Nicole K GanciDepartment of Pathology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-8037-607X
Christine H MillerDepartment of Pathology, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-2176-9516
Eric GaiThe Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-9011-0347
Donald M RodriguezDepartment of Pathology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-2534-1480
Bridgett K Ryan-PayseurDepartment of Microbiology and Immunology, University of Illinois Chicago, Chicago, IL, USA.
Ryan K DuncombeDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-7414-0987
Erin J AdamsDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-6271-8574
Mark Maienschein-ClineResearch Informatics Core, Research Resources Center, University of Illinois Chicago, Chicago, IL, USA.ORCID 0000-0001-6619-6788
Nancy E FreitagDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, IL, USA.
Ronald N GermainLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-1495-9143
Harikesh S WongThe Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-0313-6600
Peter A SavageDepartment of Pathology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-2506-7717
Funding
MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1MINTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7McGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MSpecificity of regulatory T cell suppression during infectionU01AI154560 · NIAID · UNIVERSITY OF CHICAGO · PI SAVAGE, PETER AIDAN · 2021 to 2025
$2.0MSpecificity and function of memory-phenotype CD8+ T cells in the tumor environmentF30CA236061 · NCI · UNIVERSITY OF CHICAGO · PI MILLER, CHRISTINE · 2019 to 2022
$203kImpact of TCR-pMHC affinity on prostate-specific CD4+ T cell development and functionF30CA247264 · NCI · UNIVERSITY OF CHICAGO · PI RODRIGUEZ, DONALD MIGUEL · 2020 to 2022
$153kNCI NIH HHS F30 CA236061NCI NIH HHS F30 CA247264NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS T32 AI007090NIAID NIH HHS U01 AI154560NIDA NIH HHS 75N95020D00005NIGMS NIH HHS T32 GM007281ORFDO NIH HHS 75N99020D00005
Abstract
During infections, CD4
Indexed as
AutoantigensAutoimmunityImmune ToleranceT-Lymphocytes, RegulatoryAnimalsFemaleForkhead Transcription FactorsMaleMiceMice, Inbred C57BLMice, TransgenicAutoantigensForkhead Transcription FactorsFoxp3 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.