Evidence map›Paper›PMID 40014688›Full record

ArticleMacromolecular rapid communications2025

Supramolecular Polymer Bottlebrushes: In Situ Assessment of Noncovalent Assemblies in Human Serum by Analytical Ultracentrifugation.

Ilya Anufriev, Tobias Klein, Stephanie Hoeppener, Johannes C Brendel, Ivo Nischang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular rapid communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ilya AnufrievLaboratory of Organic and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstr. 10, 07743, Jena, Germany.
Tobias KleinLaboratory of Organic and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstr. 10, 07743, Jena, Germany.
Stephanie HoeppenerLaboratory of Organic and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstr. 10, 07743, Jena, Germany.
Johannes C BrendelMacromolecular Chemistry I, University of Bayreuth, Universitätsstr. 30, 95447, Bayreuth, Germany.
Ivo NischangLaboratory of Organic and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstr. 10, 07743, Jena, Germany.ORCID https://orcid.org/0000-0001-6182-5215

Funding

Collaborative Research Center PolyTarget 316213987Deutsche Forschungsgemeinschaft 471397362Emmy-Noether Programme 358263073
6 · The paper itself

Abstract

For nanomedical targeting and drug delivery purposes, the noncovalent assembly of polymer building blocks into defined nanostructures is an intense area of research. One of the key assets desirable to know for the potential nanocarrier is the stability under conditions close to those in application scenarios. Here, a series of polymer building blocks based on poly(ethylene glycol) (PEG), which comprise a functional end group facilitating self-assembly into supramolecular polymer bottlebrushes (SPBs), is hydrodynamically studied. The building blocks, and consequently the assemblies, are labeled with a cyanine5 (Cy5) dye enabling selective tracing of the materials in human serum (HS) in analytical ultracentrifugation (AUC) experiments. Our experiments reveal a long-term stability of the noncovalent assemblies over one month of storage of the materials in HS at body temperature. At the same time, the interaction of some of the Cy5 moieties with the transport protein human serum albumin (HSA) is evidenced.

Indexed as

Polyethylene GlycolsPolymersCarbocyaninesHumansMacromolecular SubstancesMolecular StructureSerum Albumin, HumanUltracentrifugationCarbocyaninescyanine dye 5Macromolecular SubstancesPolyethylene GlycolsPolymersSerum Albumin, Humananalytical ultracentrifugationhuman serumstabilitysupramolecular polymer bottlebrushes

Identifiers

PMID40014688
PMCPMC12087737

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.