Evidence map›Paper›PMID 40014668›Full record

ArticleACS infectious diseases2025

Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of

Simon R Green, Justin R Harrison, Stephen Thompson, Dinakaran Murugesan, M Daben J Libardo, Curtis A Engelhart, Jaclynn Meshanni, Daniel Fletcher, Paul Scullion, Darren Edwards and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Simon R GreenDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.ORCID 0000-0001-5054-4792
Justin R HarrisonDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Stephen ThompsonDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Dinakaran MurugesanDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
M Daben J LibardoTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Rockville Pike, Bethesda, Maryland 9000, United States.
Curtis A EngelhartDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States.
Jaclynn MeshanniDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States.
Daniel FletcherDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Paul ScullionDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Darren EdwardsDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Ola EpemoluDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Nicole MutterDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Yoko ShishikuraDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Jennifer RileyDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Thomas R IoergerDepartment of Computer Science and Engineering, Texas A&M University, College Station, Texas 77843, United States.
Jose Juan Roca GuillénGlobal Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
Laura Guijarro LópezGlobal Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
Kevin D ReadDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.ORCID 0000-0002-8536-0130
Clifton E BarryTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Rockville Pike, Bethesda, Maryland 9000, United States.
Dirk SchnappingerDepartment of Computer Science and Engineering, Texas A&M University, College Station, Texas 77843, United States.
Paul G WyattDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Helena I M BoshoffTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Rockville Pike, Bethesda, Maryland 9000, United States.ORCID 0000-0002-4333-206X
Laura A T CleghornDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.ORCID 0000-0001-6218-0092

Funding

Gates Foundation INV-004761Gates Foundation INV-009414Wellcome TrustWellcome Trust 100195/Z/12/Z
6 · The paper itself

Abstract

Although not currently in the infectious disease spotlight, there is still a pressing need for new agents to treat tuberculosis caused by

Indexed as

Antitubercular AgentsBacterial ProteinsMycobacterium tuberculosisHumansMicrobial Sensitivity TestsStructure-Activity RelationshipTuberculosisAntitubercular AgentsBacterial Proteinsmetabolic instabilitypentafluorophenylPks13tuberculosis

Identifiers

PMID40014668
PMCPMC11915372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.