ArticleMMWR. Morbidity and mortality weekly report2025
Trends in Cervical Precancers Identified Through Population-Based Surveillance - Human Papillomavirus Vaccine Impact Monitoring Project, Five Sites, United States, 2008-2022.
Article in MMWR. Morbidity and mortality weekly report, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative effectiveness and immunogenicity of single-dose and multi-dose human papillomavirus vaccination: a systematic review.BMC public health · 2025Pooled it
- Human Papillomavirus vaccine knowledge and recommendation practice among primary care providers, Almaty, Kazakhstan - 2023.Human vaccines & immunotherapeutics · 2026Article
- Artificial intelligence-assisted histopathological diagnosis of endocervical gastric-type adenocarcinoma: a multicenter model development and validation study.The journal of pathology. Clinical research · 2026Article
- Application and Impact of Quality Assurance Dashboards in Cytology Laboratories-The CytoLog Application.Cytopathology : official journal of the British Society for Clinical Cytology · 2026Article
- Understanding HPV Vaccine Uptake Among American Indian and Alaska Native College Students: A Scoping Review.International journal of environmental research and public health · 2026Article
- The Cancer That Could Disappear.Clinical journal of oncology nursing · 2026Article
- Virus infections and cancers: from mechanisms to therapeutics.Molecular biomedicine · 2026Review
- Real-world Impact of HPV Vaccination on CIN2+ Reduction: A Meta-analysis of Observational Studies Assessing Variation by Age, Coverage, and Vaccine Type.Open forum infectious diseases · 2026Review
- Decreases in Human Papillomavirus Vaccine Types 16 and 18 in Cervical Precancers: HPV-IMPACT, 2008 to 2019.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Cost-Effectiveness of Nationwide HPV Vaccination in Girls in Kazakhstan: A UNIVAC-Based Analysis.Vaccines · 2026Article
- Combating infectious diseases in a fragmented world.Nature medicine · 2026Article
- Declines in cervical cancer incidence among young women in the United States.Journal of the National Cancer Institute · 2026Article
- Search for Equus caballus papillomavirus type 2 in tissues of asymptomatic horses in southern brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Female liver transplant recipients are at increased risk of developing cervical cancer: A global multicenter study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Cervical Adenocarcinoma In Situ in Young Nulliparous Patient with Persistent ASC-US and Multiple-Type HPV Infections Without HPV 16 and 18 Types-Case Report.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- #DidYouKnow: Physician engagement online and offline is mission critical to promote accurate and impactful cervical cancer information dissemination.Gynecologic oncology reports · 2026Article
- Correlation of vaginal lactic acid bacteria changes with high-risk human papillomavirus-infected cervical intraepithelial neoplasia and nomogram model.Frontiers in medicine · 2026Article
- Global trends and future projections of cervical cancer burden: an integrated analysis of GBD 2021, UN population and WHO HPV vaccination data.Frontiers in public health · 2026Article
- Two decades of the HPV vaccine: its promise, progress, prospects, projections, and posterity.Lancet regional health. Americas · 2025Review
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2006, human papillomavirus (HPV) vaccine was first recommended in the United States to prevent cancers and other diseases caused by HPV; vaccination coverage increased steadily through 2021, and increasing numbers of young women had received HPV vaccine as children or adolescents. Since 2008, CDC has monitored incidence of precancerous lesions (cervical intraepithelial neoplasia [CIN] grades 2-3 and adenocarcinoma in situ [AIS], collectively CIN2+), which are detected through cervical cancer screening and can be used as an intermediate outcome for monitoring vaccination impact, via the five-site Human Papillomavirus Vaccine Impact Monitoring Project. This analysis describes trends in incidence of CIN2+ and CIN3+ (i.e., CIN grade 3 and AIS) lesions during 2008-2022. Among women aged 20-24 years who were screened for cervical cancer, rates during 2008-2022 decreased for CIN2+ by 79%, and for CIN3+ by 80%. In the same period, CIN3+ rates among screened women aged 25-29 years decreased by 37%. These data are consistent with considerable impact of HPV vaccination for preventing cervical precancers among women in the age groups most likely to have been vaccinated, and support existing recommendations to vaccinate children at the routinely recommended ages as a cancer prevention measure.
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