Evidence map›Paper›PMID 40014500›Full record

ArticleBehavioral neuroscience2025

Therapeutic effects of metformin on cocaine conditioned place preference and locomotion.

Edith Hernandez, Mahamed Mohamud Abdulahi, Peter Hunsader, Aditi Alshi, Sarah Ufearo, Ayden Reed, Sade Spencer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioral neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Edith HernandezMolecular Pharmacology and Therapeutics Program, Department of Pharmacology, University of Minnesota Medical School.
Mahamed Mohamud AbdulahiDepartment of Pharmacology, University of Minnesota Medical School.
Peter HunsaderDepartment of Pharmacology, University of Minnesota Medical School.ORCID 0009-0008-8801-9705
Aditi AlshiDepartment of Pharmacology, University of Minnesota Medical School.
Sarah UfearoCollege of Biological Sciences, University of Minnesota.
Ayden ReedDepartment of Pharmacology, University of Minnesota Medical School.
Sade SpencerMolecular Pharmacology and Therapeutics Program, Department of Pharmacology, University of Minnesota Medical School.ORCID 0000-0001-8663-9056

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008244 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SHIMIZU, YOJI · 1988 to 2024
$13.6M
Targeting adenosine monophosphate activated protein kinase (AMPK) to reduce cocaine relapseR21DA050822 · NIDA · UNIVERSITY OF MINNESOTA · PI SPENCER, SADE MONIQUE · 2022 to 2023
$426k
Repurposing Metformin as a Treatment for Cocaine Use DisorderF30DA059988 · NIDA · UNIVERSITY OF MINNESOTA · PI Edith Hernandez · 2023 to 2026
$195k
NIDA NIH HHS F30 DA059988NIDA NIH HHS R21 DA050822NIGMS NIH HHS T32 GM008244NIH HHS
6 · The paper itself

Abstract

Lack of Food and Drug Administration-approved treatments for cocaine use disorder contributes to high rates of treatment attrition, relapse, and overdose. Metformin is a Type 2 diabetes drug being investigated for multiple new therapeutic indications. This study set out to determine whether metformin would impact the conditioned rewarding effects of cocaine in an abbreviated or standard two-chamber conditioned place preference (CPP) assay. Adult male (

Indexed as

CocaineConditioning, ClassicalConditioning, PsychologicalLocomotionMetforminAnimalsCocaine-Related DisordersFemaleHypoglycemic AgentsMaleRatsRats, Sprague-DawleyRewardSex CharacteristicsCocaineHypoglycemic AgentsMetformin

Identifiers

PMID40014500
PMCPMC12053506

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.