Evidence map›Paper›PMID 40014464›Full record

ArticleACS infectious diseases2025

C7-Substituted Quinolines as Potent Inhibitors of AdeG Efflux Pumps in

Yiling Zhu, Charlotte K Hind, Taha Al-Adhami, Matthew E Wand, Melanie Clifford, J Mark Sutton, Khondaker Miraz Rahman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yiling ZhuUK Health Security Agency, Research and Development Institute, National Infection Service, Porton Down, Salisbury, Wiltshire SP4 0JG, U.K.
Charlotte K HindUK Health Security Agency, Research and Development Institute, National Infection Service, Porton Down, Salisbury, Wiltshire SP4 0JG, U.K.ORCID 0000-0002-3763-3106
Taha Al-AdhamiInstitute of Pharmaceutical Science, School of Cancer & Pharmaceutical Sciences, King's College London, London SE1 9NH, U.K.
Matthew E WandUK Health Security Agency, Research and Development Institute, National Infection Service, Porton Down, Salisbury, Wiltshire SP4 0JG, U.K.
Melanie CliffordUK Health Security Agency, Research and Development Institute, National Infection Service, Porton Down, Salisbury, Wiltshire SP4 0JG, U.K.
J Mark SuttonUK Health Security Agency, Research and Development Institute, National Infection Service, Porton Down, Salisbury, Wiltshire SP4 0JG, U.K.
Khondaker Miraz RahmanInstitute of Pharmaceutical Science, School of Cancer & Pharmaceutical Sciences, King's College London, London SE1 9NH, U.K.ORCID 0000-0001-8566-8648

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Efflux, mediated by a series of multidrug efflux pumps, is a major contributor to antibiotic resistance in Gram-negative bacteria. Efflux pump inhibitors (EPIs), which can block efflux, have the potential to be used as adjuvant therapies to resensitize bacteria to existing antibiotics. In this study, 36 quinoline-based compounds were synthesized as potential EPIs targeting resistance nodulation division (RND) family pumps in the multidrug-resistant pathogen

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsBacterial ProteinsMembrane Transport ProteinsQuinolinesAnimalsChloramphenicolDrug Resistance, Multiple, BacterialMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial ProteinsChloramphenicolMembrane Transport ProteinsQuinolinesAcinetobacter baumanniiAntimicrobial resistanceC7-substituted quinolinesefflux pump inhibitorsRND efflux pump

Identifiers

PMID40014464
PMCPMC11915368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.