Evidence map›Paper›PMID 40014296›Full record

ArticleHepatology international2025

Acute kidney injury stage 1a increases mortality of patients with cirrhosis: a prospective multicenter cohort study.

Ângelo Z Mattos, Caroline Machado Rotta Dornelles, Leonardo de Lucca Schiavon, Liliana Sampaio Costa Mendes, Roberto José de Carvalho Filho, Liana Codes, Alberto Queiroz Farias, Mário Reis Álvares-da-Silva, Carlos Terra, Gustavo Pereira and 10 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Hepatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ângelo Z MattosGraduate Program in Medicine: Hepatology, Federal University of Health Sciences of Porto Alegre, 245 Sarmento Leite Street, Porto Alegre, RS, Brazil. angeloz@ufcspa.edu.br.ORCID http://orcid.org/0000-0002-3063-0199
Caroline Machado Rotta DornellesGraduate Program in Medicine: Hepatology, Federal University of Health Sciences of Porto Alegre, 245 Sarmento Leite Street, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0009-0000-6218-2602
Leonardo de Lucca SchiavonDivision of Gastroenterology, Federal University of Santa Catarina, Professora Maria Flora Pausewang Street, Florianópolis, SC, Brazil.ORCID http://orcid.org/0000-0003-4340-6820
Liliana Sampaio Costa MendesGastroenterology and Hepatology Unit, Hospital de Base do Distrito Federal, SMHS - Special Area Block 101 - South Wing, Brasília, DF, Brazil.ORCID http://orcid.org/0000-0003-2447-8845
Roberto José de Carvalho FilhoDivision of Gastroenterology, Federal University of São Paulo, 740 Botucatu Street, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-9795-5705
Liana CodesGastroenterology and Hepatology Unit, Hospital Português, 914 Princesa Isabel Avenue, Salvador, BA, Brazil.ORCID http://orcid.org/0000-0001-5178-8705
Alberto Queiroz FariasDepartment of Gastroenterology, University of São Paulo, 455 Doutor Arnaldo Avenue, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-5572-663X
Mário Reis Álvares-da-SilvaDivision of Gastroenterology, Hospital de Clínicas de Porto Alegre, 2350 Ramiro Barcelos Street, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-5001-246X
Carlos TerraGastroenterology and Hepatology Unit, State University of Rio de Janeiro, 381 Marechal Rondon Avenue, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0003-3069-128X
Gustavo PereiraGastroenterology and Hepatology Unit, Hospital Federal de Bonsucesso, 616 Londres Avenue, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0003-2768-9605
Muriel ManicaGraduate Program in Medicine: Hepatology, Federal University of Health Sciences of Porto Alegre, 245 Sarmento Leite Street, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-4373-4368
Helena Marcon BischoffDivision of Internal Medicine, Hospital de Clínicas de Porto Alegre, 2350 Ramiro Barcelos Street, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0001-6516-3327
Janaína Luz Narciso-SchiavonDivision of Gastroenterology, Federal University of Santa Catarina, Professora Maria Flora Pausewang Street, Florianópolis, SC, Brazil.ORCID http://orcid.org/0000-0002-6228-4120
Silas Gustavo Barboza RomeresGastroenterology and Hepatology Unit, Hospital de Base do Distrito Federal, SMHS - Special Area Block 101 - South Wing, Brasília, DF, Brazil.ORCID http://orcid.org/0000-0003-0291-0633
Jéssica Bastos GarciaDivision of Gastroenterology, Federal University of São Paulo, 740 Botucatu Street, São Paulo, SP, Brazil.ORCID http://orcid.org/0009-0006-8777-4130
Paulo Lisboa BittencourtGastroenterology and Hepatology Unit, Hospital Português, 914 Princesa Isabel Avenue, Salvador, BA, Brazil.ORCID http://orcid.org/0000-0003-0883-4870
Rafael Oliveira XimenesDepartment of Gastroenterology, University of São Paulo, 455 Doutor Arnaldo Avenue, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-8689-7987
Raul Salinas ArrojoDivision of Gastroenterology, Hospital de Clínicas de Porto Alegre, 2350 Ramiro Barcelos Street, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0009-0005-6630-7130
Angelo A MattosGraduate Program in Medicine: Hepatology, Federal University of Health Sciences of Porto Alegre, 245 Sarmento Leite Street, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0003-2417-9765
Alliance of Brazilian Centers for Cirrhosis Care – the ABC Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsAcute kidney injury is a severe complication of cirrhosis. However, the impact of mild decreases in renal function is controversial. This study aims to evaluate the prognosis of the different stages of acute kidney injury in cirrhosis.

methodsThis is a multicenter prospective cohort study of patients hospitalized for acute decompensation of cirrhosis, with serum creatinine values measured at least twice. Primary outcome was mortality (in-hospital, 30 days, 90 days and 12 months).

resultsNine hundred twenty-eight patients were included in the study. Acute kidney injury was diagnosed in 505 patients (stages 1a-21.6%, 1b-27.5%, 2-28.1%, 3-22.8%). Mortality rates of patients with acute kidney injury stage 1a were significantly higher than those of individuals without acute kidney injury (in-hospital-19.3% vs 4.7%; 30-day-21.8% vs 6.7%; 90-day-35.2% vs 17.5%; 12-month-54.1% vs 37.1%; p < 0.05 for all comparisons). Mortality rates were even higher for acute kidney injury stages 1b, 2 and 3. Survival analysis demonstrated that patients without acute kidney injury performed significantly better than those with any stage of acute kidney injury (p < 0.01). Acute kidney injury stages 1a, 1b, 2 and 3 were independently associated with survival in the multivariate analysis (p < 0.01).

conclusionsPatients hospitalized for acute decompensation of cirrhosis who develop acute kidney injury have significantly higher mortality rates than those who do not develop this complication. This is true even for the mildest stages of acute kidney injury (stage 1a) and remains so at different time-points, supporting recommendations for earlier treatments.

Indexed as

Acute Kidney InjuryLiver CirrhosisAgedCohort StudiesCreatinineFemaleHospital MortalityHumansMaleMiddle AgedPrognosisProspective StudiesSeverity of Illness IndexCreatinineChronic liver diseaseHepatorenal syndromeLong-termMultivariate analysisPhenotypeRenal functionSerum creatinineStagingSurvivalTreatment response

Identifiers

PMID40014296

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.