Evidence map›Paper›PMID 40014283›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2025

GSK1016790A, a TRPV4 Agonist, Repairs Spermatogenic Dysfunction Caused By Diabetes.

Xingqi Meng, Xiaohan Tang, Lixuan Peng, Yuyan Xiang, Cuilan Zhou, Wenyu Cao, Yang Xu, Cuiying Peng, Yichun Li, Suyun Li

Abstract read
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xingqi Meng *Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Xiaohan Tang *Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Lixuan PengClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Yuyan XiangClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Cuilan ZhouClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Wenyu CaoClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Yang XuDepartment of Physiology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Cuiying PengDepartment of Cell Biology and Genetics, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Yichun LiDepartment of Obstetrics & Gynaecology, The Second Affiliated Hospital University of South China, Hengyang, 421001, Hunan, China. 277112627@qq.com.
Suyun LiClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. lsy1631632021@163.com.ORCID 0000-0001-8008-3253

Funding

Natural Science Foundation of Hunan Province No.2023JJ60358
6 · The paper itself

Abstract

As a devastating metabolic disease, diabetic testicular damage can lead to impaired spermatogenesis and sexual dysfunction. Transient receptor potential cation channel subfamily vanilloid 4 (TRPV4) plays complex roles in the pathogenesis of diabetes and its complications and plays a major role in the development of apoptosis and related mechanisms. This study aimed to investigate the effects of the TRPV4 agonist GSK1016790A on sperm parameters, spermatogenic cell apoptosis and testicular histopathology in STZ-induced diabetic mice. A model of diabetes was induced in 8-week-old male ICR mice by an intraperitoneal injection of STZ for five consecutive days. At week 7, the mice were intraperitoneally injected with the TRPV4 agonist GSK1016790A or normal saline (NS) for 7 days. At week 8, the animals were sacrificed. The results revealed that the expression of TRPV4 in the testes of STZ-induced diabetic mice decreased, and the testes exhibited the destruction of tissue structure, decreases in the total sperm count and viability, an increase in the sperm deformity rate, and an increase in apoptosis. These symptoms were reversed by increased TRPV4 expression following the injection of the TRPV4 agonist GSK1016790A. Increased TRPV4 expression can ameliorate cell apoptosis in the STZ-induced testes of diabetic mice and alleviate spermatogenic dysfunction in the testes.

Indexed as

Diabetes Mellitus, ExperimentalLeucineSpermatogenesisSpermatozoaSulfonamidesTestisTRPV Cation ChannelsAnimalsApoptosisMaleMiceMice, Inbred ICRLeucineN-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamideSulfonamidesTrpv4 protein, mouseTRPV Cation ChannelsApoptosisDiabetesGSK1016790ASpermatogenesis dysfunctionSTZTRPV4

Identifiers

PMID40014283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.