Evidence map›Paper›PMID 40014235›Full record

ArticleIrish journal of medical science2025

Fluoroquinolones and tendon injury: a 5-year review of Irish national incident and claims data.

Mark McCullagh, Natasha Coen, Cathal O'Keeffe

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Article in Irish journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Mark McCullaghTreasury Dock, State Claims Agency, North Wall Quay, Dublin, D01 A9T8, Ireland. mark.mccullagh@ntma.ie.ORCID http://orcid.org/0000-0002-5316-3941
Natasha CoenTreasury Dock, State Claims Agency, North Wall Quay, Dublin, D01 A9T8, Ireland.
Cathal O'KeeffeTreasury Dock, State Claims Agency, North Wall Quay, Dublin, D01 A9T8, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimIn 2018, the European Medicines Agency strengthened warnings in relation to fluoroquinolone (FQ)-associated tendon injury. There is a lack of published data on FQs and tendon injury in an Irish context. The aim of the study was to investigate incidents and claims relating to FQs and tendon injury through an analysis of National Incident Management System (NIMS) data.

methodsThe NIMS database was searched for incidents created between 1st June 2018 and 31st May 2023 which involved any FQ and referenced tendon injury. The incident data was analysed under predetermined field headings. NIMS was also searched for clinical claims involving any FQ with a Claim Finalised Date between 1st June 2018 and 31st May 2023. The claims were analysed to identify common themes.

resultsThe study identified 20 incidents which related to FQs and tendon injury, although only six reported an actual tendon injury. In 15 (75%) of the incidents, the prescription of a FQ was deemed inappropriate by the reporter. The study found four finalised claims, all of which related to bilateral Achilles tendon rupture following FQ exposure. In all four cases, the patient was aged over 60 and the injury occurred within days of commencing treatment.

conclusionsThis study confirms that FQs continue to be prescribed inappropriately in high-risk patients and that incidents of tendon injury following FQ exposure continue to occur despite regulatory moves of raise awareness of this issue. Additional measures to minimise the risk of avoidable patient harm may be warranted.

Indexed as

Anti-Bacterial AgentsFluoroquinolonesTendon InjuriesAgedDatabases, FactualFemaleHumansIrelandMaleMiddle AgedAnti-Bacterial AgentsFluoroquinolonesAdverse drug reactionsAntibioticsMedication safety

Identifiers

PMID40014235

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