Evidence map›Paper›PMID 40014212›Full record

SynthesisCurrent gastroenterology reports2025

Global Prevalence of Anxiety in Gastroenterology and Hepatology Outpatients: A Systematic Review and Meta-Analysis.

Ben Storer, Monique Holden, Kelly Ann Kershaw, Taylor A Braund, Cassandra Chakouch, Matthew James Coleshill, Sam Haffar, Samuel Harvey, Gemma Sicouri, Jill Newby and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Current gastroenterology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ben StorerClinical Research Department, The Black Dog Institute, Sydney, Australia.
Monique HoldenClinical Research Department, The Black Dog Institute, Sydney, Australia.
Kelly Ann KershawClinical Research Department, The Black Dog Institute, Sydney, Australia.
Taylor A BraundClinical Research Department, The Black Dog Institute, Sydney, Australia.
Cassandra ChakouchClinical Research Department, The Black Dog Institute, Sydney, Australia.
Matthew James ColeshillClinical Research Department, The Black Dog Institute, Sydney, Australia.
Sam HaffarClinical Research Department, The Black Dog Institute, Sydney, Australia.
Samuel HarveyClinical Research Department, The Black Dog Institute, Sydney, Australia.
Gemma SicouriClinical Research Department, The Black Dog Institute, Sydney, Australia.
Jill NewbyClinical Research Department, The Black Dog Institute, Sydney, Australia.
Michael MurphyClinical Research Department, The Black Dog Institute, Sydney, Australia. michael.murphy@unsw.edu.au.

Funding

National Health and Medical Research Council 2008839
6 · The paper itself

Abstract

purpose of reviewMany patients with chronic health conditions experience anxiety, which can have significant implications on physical health outcomes and quality of life. This systematic review and meta-analysis aimed to examine the prevalence of anxiety in gastroenterology and hepatology outpatients, across factors such as physical health condition, type of anxiety, and patient demographics, with the intention to support clinicians in providing effective patient care. RECENT

findingsSeveral recent systematic reviews have been published investigating rates of anxiety in different outpatient settings, and have found consistently high rates across the dermatology, endocrinology, cardiology and respiratory/sleep medicine fields, ranging between 25.1% and 30.3%. Whilst there are established links between gastroenterology and hepatology conditions with anxiety, there has yet to be a study estimating the overall global prevalence of anxiety in this outpatient setting. PubMed, Embase, Cochrane and PsycINFO databases were searched from database inception to January 2023 for studies reporting anxiety in gastroenterology and hepatology outpatients ≥ 16 years of age. Prevalence was extracted from self-report questionnaires, diagnostic interviews, and records. The final meta-analysis included 81 studies, with 28,334 participants. Pooled prevalence of anxiety was 31.2% (95% CI 28.2%-34.4%). Subgroup analyses identified significant differences in prevalence across anxiety type, with health anxiety showing the highest prevalence at 23.7%, followed by generalised anxiety 14.5%, specific phobia 12.5%, panic disorder/agoraphobia 12.2%, social anxiety 11.3%, post-traumatic stress disorder 4.9%, and obsessive-compulsive disorder 4.2%. No other significant differences were found. Anxiety is thus common amongst gastroenterology and hepatology outpatients, and so it is important that careful consideration be given to the identification and management of anxiety in these settings.

Indexed as

AnxietyGastrointestinal DiseasesLiver DiseasesOutpatientsGastroenterologyGlobal HealthHumansPrevalenceAnxiety disordersGastroenterologyHepatologyOutpatientsPsychiatry

Identifiers

PMID40014212
PMCPMC11868238

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.