Evidence map›Paper›PMID 40014198›Full record

ArticleMolecular imaging and biology2025

Quantifying Molecular Changes in the Preeclamptic Rat Placenta with Targeted Contrast-Enhanced Ultrasound Imaging.

Lili Shi, Allan K N Alencar, Kenneth F Swan, Dylan J Lawrence, Gabriella Pridjian, Carolyn L Bayer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lili ShiDepartment of Biomedical Engineering, Tulane University, 500 Lindy Boggs Center, New Orleans, LA, 70118, USA.
Allan K N AlencarDepartment of Biomedical Engineering, Tulane University, 500 Lindy Boggs Center, New Orleans, LA, 70118, USA.
Kenneth F SwanDepartment of Obstetrics & Gynecology, Tulane University, New Orleans, LA, 70112, USA.
Dylan J LawrenceDepartment of Biomedical Engineering, Tulane University, 500 Lindy Boggs Center, New Orleans, LA, 70118, USA.
Gabriella PridjianDepartment of Obstetrics & Gynecology, Tulane University, New Orleans, LA, 70112, USA.
Carolyn L BayerDepartment of Biomedical Engineering, Tulane University, 500 Lindy Boggs Center, New Orleans, LA, 70118, USA. carolynb@tulane.edu.ORCID http://orcid.org/0000-0003-0947-6892

Funding

Placental Functional Imaging to Predict Preeclampsia Therapeutic OutcomesR01HD097466 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI BAYER, CAROLYN LOUISE · 2019 to 2023
$1.6M
National Institute of Child Health and Human Development R01HD097466NICHD NIH HHS R01 HD097466
6 · The paper itself

Abstract

purposeAbnormal placental remodeling is linked to various pregnancy-related diseases, including preeclampsia (PE). This study applies a bicompartmental (BCM) model to quantify molecular expression changes in the placenta, indicative of abnormal placental remodeling, and evaluates the effectiveness of targeted contrast-enhanced ultrasound (T-CEUS) in detecting the abnormal placental vasculature. The BCM model provides high temporal resolution and differentiation of anatomical artery structures within the placenta by analyzing the distribution of contrast agents.

methodsA targeted contrast agent (TCA) composed of gas-filled microbubbles (MB), with a surface-conjugated peptide to target α

resultsThe RUPP group showed a significant reduction in the value of

conclusionsThe BCM method differentiates molecular changes associated with the abnormal placental development associated with PE. It also reveals more intricate internal anatomical structures of the placenta in comparison to dTE and LE, suggesting that the BCM could enhance early detection and monitoring of PE.

Indexed as

Contrast MediaPlacentaPre-EclampsiaAnimalsFemaleMicrobubblesPregnancyRatsRats, Sprague-DawleyUltrasonographyContrast MediaBicompartmental modelBinding constantContrast-enhanced ultrasoundPlacentaPreeclampsiaTargeted contrast agent

Identifiers

PMID40014198
PMCPMC12062038

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.