SynthesisArchives of dermatological research2025
From wheal to wellness: efficacy and safety of ligelizumab in chronic spontaneous urticaria: a systematic review and meta-analysis.
Synthesis in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of different doses of ligelizumab in patients with chronic spontaneous urticaria: a systematic review and meta-analysis of randomized controlled trials with GRADE evaluation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic spontaneous urticaria (CSU) is characterized by persistent hives and itching that lasts longer than six weeks. Ligelizumab, a humanized monoclonal antibody specifically targeting IgE, has emerged as a promising option for managing CSU. This study evaluates the effectiveness and safety of ligelizumab for this debilitating condition. A comprehensive literature search was conducted at PubMed, Cochrane Library, Google Scholar, and ClinicalTrials.gov to identify relevant studies published until December 2024. The review included randomized controlled trials that compared ligelizumab with a placebo. Our meta-analysis of 2581 patients found that ligelizumab significantly improves outcomes in chronic spontaneous urticaria. A dose-dependent response was observed, with 24 mg being non-superior to placebo. Doses of 72 mg significantly reduced Itch Severity Score (MD: - 3.54; 95% CI - 4.36 to - 2.73; P < 0.00001), Urticaria Activity Score (UAS7) (MD: - 9.79; 95% CI - 10.65 to - 8.93; P < 0.00001), provided complete UAS7 response (UAS7 = 0) (OR: 7.30; 95% CI 2.99 to 17.83; P < 0.0001), and Angioedema free weeks (MD: 2.22; 95% CI 1.63 to 2.82; P < 0.00001), with further improvements noted at the 120 mg dose. Statistically significant results were also observed for the Dermatological Life Quality Index and Hives Severity Score. No significant adverse effects were reported with ligelizumab 72 mg, but very mild adverse effects were discovered with the 120 mg dose. Ligelizumab, at doses of 72 mg and 120 mg, effectively manages CSU by reducing symptoms and improving overall quality of life compared to placebo, although 120 mg Ligelizumab is associated with mild Adverse Events.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.