Evidence map›Paper›PMID 40014086›Full record

ReviewClinical research in cardiology : official journal of the German Cardiac Society2026

Percutaneous left atrial appendage closure for stroke prevention: current challenges and future perspectives.

Carla Rochira, Alessandro Mazzapicchi, Salvatore Davide Tomasello, Salvatore Adriano Azzarelli, Alessandro Di Giorgio, Francesco Scardaci, Vincenzo Argentino, Francesco Amico

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carla RochiraDivision of Cardiology, Azienda Ospedaliero-Universitaria Policlinico "G. Rodolico - San Marco", University of Catania, Catania, Italy.
Alessandro MazzapicchiDivision of Cardiology, Azienda Ospedaliero-Universitaria Policlinico "Sant'Orsola", University of Bologna, Bologna, Italy.
Salvatore Davide TomaselloCatheterization Laboratory and Cardiovascular Interventional Unit, Division of Cardiology, Cannizzaro Hospital, University of Catania, Via Antonello Pitagora da Samo 4, Acicastello, 95021, Catania,, Italy. davtomasello@gmail.com.
Salvatore Adriano AzzarelliCatheterization Laboratory and Cardiovascular Interventional Unit, Division of Cardiology, Cannizzaro Hospital, University of Catania, Via Antonello Pitagora da Samo 4, Acicastello, 95021, Catania,, Italy.
Alessandro Di GiorgioCatheterization Laboratory and Cardiovascular Interventional Unit, Division of Cardiology, Cannizzaro Hospital, University of Catania, Via Antonello Pitagora da Samo 4, Acicastello, 95021, Catania,, Italy.
Francesco ScardaciCatheterization Laboratory and Cardiovascular Interventional Unit, Division of Cardiology, Cannizzaro Hospital, University of Catania, Via Antonello Pitagora da Samo 4, Acicastello, 95021, Catania,, Italy.
Vincenzo ArgentinoCatheterization Laboratory and Cardiovascular Interventional Unit, Division of Cardiology, Cannizzaro Hospital, University of Catania, Via Antonello Pitagora da Samo 4, Acicastello, 95021, Catania,, Italy.
Francesco AmicoCatheterization Laboratory and Cardiovascular Interventional Unit, Division of Cardiology, Cannizzaro Hospital, University of Catania, Via Antonello Pitagora da Samo 4, Acicastello, 95021, Catania,, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke accounts for significant morbidity and mortality worldwide. Accordingly, appropriate prevention is crucial to reduce the global burden of stroke. Percutaneous left atrial appendage closure (LAAC) is a viable approach for preventing cardioembolic stroke in patients with non-valvular atrial fibrillation who have a contraindication to long-term oral anticoagulation due to a non-reversible cause. In the last 2 decades, percutaneous LAAC has become a rapidly evolving field, with multiple devices approved or under clinical development. However, several issues remain, including limited high-quality evidence, late adverse events, and unclear post-procedural antithrombotic therapy. This review offers an up-to-date perspective on percutaneous LAAC, concentrating on current challenges and unmet needs.

Indexed as

Atrial AppendageAtrial FibrillationCardiac CatheterizationStrokeHumansLeft Atrial Appendage ClosureSeptal Occluder DeviceLeft atrial appendage closureNonvalvular atrial fibrillationOral anticoagulationStrokeTransient ischemic attack

Identifiers

PMID40014086

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.