Evidence map›Paper›PMID 40014072›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2025

Recommendations for reporting preclinical radiobiological studies in targeted radionuclide therapy.

Filipa Mendes, Samantha Y A Terry, Diana Spiegelberg, Bart Cornelissen, Julie Bolcaen, Julie Nonnekens, European Working group of Radiobiology of Molecular Radionuclide Therapy

Abstract readReviewLetter
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Current status of radionuclide therapy targeting PARP in cancer: challenges and prospects.European journal of nuclear medicine and molecular imaging · 2026
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Filipa MendesDepartment of Nuclear Sciences and Engineering, Center for Nuclear Sciences and Technologies, Instituto Superior Técnico, University of Lisboa, Lisboa, Portugal.
Samantha Y A TerryDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Diana SpiegelbergDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Bart CornelissenDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Julie BolcaenCenter for Radiopharmaceutical Sciences, PSI Center for Life Sciences, PSI, Villigen, Switzerland.
Julie NonnekensDepartment of Molecular Genetics, Department of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands. j.nonnekens@erasmusmc.nl.ORCID http://orcid.org/0000-0002-9644-7522
European Working group of Radiobiology of Molecular Radionuclide Therapy

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growing interest and investments in targeted radionuclide therapy (TRT) have expanded research efforts across preclinical and clinical domains. Researchers from diverse fields, including nuclear medicine, radiochemistry, radiopharmacy, radiotherapy, biology, and physics, are increasingly focusing on TRT. Despite this, a lack of standardization in preclinical radiobiological studies hinders the evaluation and comparison of therapeutic radiopharmaceuticals across laboratories. Recognizing this, participants at the second International Workshop on Radiobiology of Molecular Radiotherapy, held in London, UK, in March 2023, emphasized the need for a consensus on nomenclature and standardized reporting guidelines in this field. The recommendations outlined here aim to address this gap by promoting consistent reporting. By adopting these standards, we hope to enhance the reproducibility, inter-laboratory comparability and visibility of preclinical TRT research, ultimately accelerating progress and amplifying its impact on the field and clinic.

Indexed as

Molecular Targeted TherapyRadiobiologyAnimalsHumansMethodology reportingRadiobiologyRadiopharmaceuticalsStandardisationTargeted radionuclide therapy

Identifiers

PMID40014072
PMCPMC12222407

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.