Evidence map›Paper›PMID 40013938›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Advances in Fecal Microbiota Transplantation for Gut Dysbiosis-Related Diseases.

Shuna Hou, Jiachen Yu, Yongshuang Li, Duoyi Zhao, Zhiyu Zhang

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Article
  7. Gut microbiota in health and disease.Molecular biomedicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shuna HouDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, China Medical University, Liao Ning, Shen Yang, 110032, P. R. China.ORCID https://orcid.org/0009-0009-2177-3209
Jiachen YuDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, China Medical University, Liao Ning, Shen Yang, 110032, P. R. China.
Yongshuang LiDepartment of general surgery, The Fourth Affiliated Hospital of China Medical University, China Medical University, Liao Ning, Shen Yang, 110032, P. R. China.
Duoyi ZhaoDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, China Medical University, Liao Ning, Shen Yang, 110032, P. R. China.
Zhiyu ZhangDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, China Medical University, Liao Ning, Shen Yang, 110032, P. R. China.ORCID https://orcid.org/0000-0001-8422-4148

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article provides an overview of the advancements in the application of fecal microbiota transplantation (FMT) in treating diseases related to intestinal dysbiosis. FMT involves the transfer of healthy donor fecal microbiota into the patient's body, aiming to restore the balance of intestinal microbiota and thereby treat a variety of intestinal diseases such as recurrent Clostridioides difficile infection (rCDI), inflammatory bowel disease (IBD), constipation, short bowel syndrome (SBS), and irritable bowel syndrome (IBS). While FMT has shown high efficacy in the treatment of rCDI, further research is needed for its application in other chronic conditions. This article elaborates on the application of FMT in intestinal diseases and the mechanisms of intestinal dysbiosis, as well as discusses key factors influencing the effectiveness of FMT, including donor selection, recipient characteristics, treatment protocols, and methods for assessing microbiota. Additionally, it emphasizes the key to successful FMT. Future research should focus on optimizing the FMT process to ensure long-term safety and explore the potential application of FMT in a broader range of medical conditions.

Indexed as

DysbiosisFecal Microbiota TransplantationGastrointestinal MicrobiomeHumansclinical efficacyClostridioides difficile infectionfecal bacteria transplantationintestinal diseasesintestinal flora

Identifiers

PMID40013938
PMCPMC11967859

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.