Evidence map›Paper›PMID 40013907›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Bioactive Inorganic Materials for Innervated Multi-Tissue Regeneration.

Hongjian Zhang, Ziyi Zhao, Chengtie Wu

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Polysaccharide based biomaterials for advanced wound healing applications.Frontiers in cellular and infection microbiology · 2026
    Review
  4. The nerve center of organ engineering.Nature communications · 2025
    Review
  5. Bioactive Calcium Silico-Phosphate Glasses Doped with MgAntibiotics (Basel, Switzerland) · 2025
    Article
  6. Bioactive Inorganic Materials for Innervated Multi-Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hongjian ZhangState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
Ziyi ZhaoState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
Chengtie WuState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.ORCID https://orcid.org/0000-0002-5986-591X

Funding

Chinese Academy of Sciences (CAS) Project for Young Scientists in Basic Research YSBR073Jiangsu Province Basic Research Key Program BK20243003Joint Research Unit Plan of Chinese Academy of Sciences 121631ZYLH20240014National Key Research and Development Program of China 2023YFB3813000National Natural Science Foundation of China 32130062National Natural Science Foundation of China 32225028Postdoctoral Research Foundation of China GZC20241821Science and Technology Commission of Shanghai Municipality 24520750100Shanghai Pilot Program for Basic Research-Chinese Academy of Science, Shanghai Branch JCYJ-SHFY-2022-003Shanghai Sailing Program 24YF2753500
6 · The paper itself

Abstract

Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated tissues still poses significant challenges due to the lack of concerns of tissue innervation. Design rationale of multifunctional biomaterials with both tissue-induction and neural induction activities shows great potential for functional tissue regeneration. Recently, the research and application of inorganic biomaterials attracts increasing attention in innervated multi-tissue regeneration, such as central nerves, bone, and skin, because of its superior tunable chemical composition, topographical structures, and physiochemical properties. More importantly, inorganic biomaterials are easily combined with other organic materials, biological factors, and external stimuli to enhance their therapeutic effects. This review presents a comprehensive overview of recent advancements of inorganic biomaterials for innervated multi-tissue regeneration. It begins with introducing classification and properties of typical inorganic biomaterials and design rationale of inorganic-based material composites. Then, recent progresses of inorganic biomaterials in regenerating various nerves and nerve-innervated tissues with functional recovery are systematically reviewed. Finally, the existing challenges and future perspectives are proposed. This review may pave the way for the direction of inorganic biomaterials and offers a new strategy for tissue regeneration in combination of innervation.

Indexed as

Biocompatible MaterialsNerve RegenerationRegenerationTissue EngineeringAnimalsHumansTissue ScaffoldsBiocompatible Materialsfunctional recoveryinnervated tissue regenerationinorganic biomaterialstissue engineering and regenerative medicine

Identifiers

PMID40013907
PMCPMC11967777

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.