Evidence map›Paper›PMID 40013898›Full record

ArticleInternational forum of allergy & rhinology2025

Deletion of Nrf2 Enhances Susceptibility to Sinonasal Inflammation After Short-Term PM

Anuj Tharakan, Asiana Gurung, Nyall R London, Stefany Lazieh, Shyam Biswal, Murugappan Ramanathan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International forum of allergy & rhinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Establishing the PMThe Journal of allergy and clinical immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anuj TharakanDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Asiana GurungDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nyall R LondonDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Stefany LaziehDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Shyam BiswalDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Murugappan RamanathanDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7612-9586

Funding

The Role of Nrf2 in Stabilizing the Epithelial Barrier in Particulate Matter Induced RhinosinusitisR01AI143731 · NIAID · JOHNS HOPKINS UNIVERSITY · PI RAMANATHAN, MURUGAPPAN · 2019 to 2023
$2.2M
Research Training in Otolaryngology ProgramR25DC021243 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI John Patrick Carey, Amanda M. Lauer · 2024 to 2026
$1.2M
NIAID NIH HHS R01 AI143731NIDCD NIH HHS DC021243NIDCD NIH HHS R25 DC021243NIH HHS R01AI143731
6 · The paper itself

Abstract

backgroundParticulate matter 2.5 (PM

methodsC57BL/6 wild-type (n = 12) and Nrf2-deficient (n = 12) mice were intranasally challenged with 400 µg of PM

resultsNrf2

conclusionThis study demonstrates that the Nrf2 antioxidant pathway is critical in controlling short-term PM

Indexed as

NF-E2-Related Factor 2Particulate MatterRhinitisSinusitisAir PollutantsAnimalsCytokinesDisease Models, AnimalDisease SusceptibilityHumansMiceMice, Inbred C57BLMice, KnockoutMucin 5ACNasal MucosaAir PollutantsCytokinesMuc5ac protein, mouseMucin 5ACNfe2l2 protein, mouseNF-E2-Related Factor 2Particulate Matterair pollutionNrf2PM2.5short‐term exposure

Identifiers

PMID40013898
PMCPMC12227289

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.