Evidence map›Paper›PMID 40013895›Full record

ReviewFuture microbiology2025

Interplay of gut microbiota in Kawasaki disease: role of gut microbiota and potential treatment strategies.

Qing Yang, Yaqing Kang, Wei Tang, Meng Li, Cuifen Zhao

Abstract readReview
In one paragraph

Review in Future microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Highlights on the Contribution of Gut Microbiota to Immune-Mediated Diseases in Childhood.Mediterranean journal of hematology and infectious diseases · 2026
    Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qing YangDepartment of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
Yaqing KangDepartment of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
Wei TangDepartment of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
Meng LiDepartment of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
Cuifen ZhaoDepartment of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.ORCID 0000-0002-7274-8371

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kawasaki disease (KD) is an acute systemic immune vasculitis with predominant involvement of the medium and small arteries. It mostly affects pediatric patients, representing the most common form of pediatric vasculitis in children less than 5 years old. Numerous diseases, especially those related to the immune system, have established links with the intestinal flora. Recent studies have investigated the intestinal flora changes throughout the management of KD. There was gut microbiota dysbiosis in pediatric KD at the acute phase, particularly the downregulation of short-chain fat acids-producing microbiota and the over-proliferation of opportunistic pathogens. The relationship between the response to therapies in individuals with KD and specific microbiota remains uncertain. Targeted microbial supplements and dietary regulation may serve as potential measures to alleviate KD complications and thus improve prognosis. This review provides an overview of the current understanding of the interplay of the gut microbiota and KD. Furthermore, it discusses the possibility of altering the gut microbiota to reinstate a healthy condition.

Indexed as

Gastrointestinal MicrobiomeMucocutaneous Lymph Node SyndromeChild, PreschoolDysbiosisFatty Acids, VolatileHumansFatty Acids, Volatileaspiringlucocorticoidgut microbiotaIVIGKawasaki diseasemicrobiota targeted strategySCFA

Identifiers

PMID40013895
PMCPMC11938985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.