Evidence map›Paper›PMID 40013665›Full record

ArticleJournal of neurophysiology2025

δ-Containing GABA

Xinguo Lu, Hong-Jin Shu, Peter M Lambert, Ann Benz, Charles F Zorumski, Steven Mennerick

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Xinguo LuDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States.
Hong-Jin ShuDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States.
Peter M LambertDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States.ORCID 0000-0001-9427-638X
Ann BenzDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States.
Charles F ZorumskiDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States.ORCID 0000-0002-9704-5154
Steven MennerickDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States.ORCID 0000-0003-0868-0664

Funding

Neuroactive steroids as novel psychiatric treatments: mechanistic studiesP50MH122379 · NIMH · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2021 to 2025
$12.2M
GABAA RECEPTOR POPULATIONS IN HIPPOCAMPUS AND THALAMUSR01MH123748 · NIMH · WASHINGTON UNIVERSITY · PI MENNERICK, STEVEN J · 2021 to 2025
$2.4M
Hippocampal circuit mechanisms of neurosteroidsF30MH126548 · NIMH · WASHINGTON UNIVERSITY · PI LAMBERT, PETER MICHAEL · 2021 to 2024
$171k
HHS | NIH | National Institute of Mental Health (NIMH) MH122379HHS | NIH | National Institute of Mental Health (NIMH) MH123748HHS | NIH | National Institute of Mental Health (NIMH) MH126548NIMH NIH HHS F30 MH126548NIMH NIH HHS P50 MH122379NIMH NIH HHS R01 MH123748
6 · The paper itself

Abstract

In medial prefrontal cortex (mPFC), fast-spiking parvalbumin (PV) interneurons regulate excitability and microcircuit oscillatory activity important for cognition. Although PV interneurons inhibit pyramidal neurons, they themselves express δ subunits of GABA

Indexed as

InterneuronsNerve NetParvalbuminsPrefrontal CortexReceptors, GABA-AAction PotentialsAnimalsInhibitory Postsynaptic PotentialsMaleMiceMice, Inbred C57BLMice, KnockoutPyramidal CellsParvalbuminsReceptors, GABA-Amedial prefrontal cortexneuronal excitabilityparvalbumin interneuronsδ-containing GABAA receptors

Identifiers

PMID40013665
PMCPMC12153516

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.