Evidence map›Paper›PMID 40013664›Full record

ArticleACS biomaterials science & engineering2025

Tanfloc-Modified Titanium Surfaces: Optimizing Blood Coagulant Activity and Stem Cell Compatibility.

Ramesh Singh, Liszt Y C Madruga, Aniruddha Savargaonkar, Alessandro F Martins, Matt J Kipper, Ketul C Popat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ramesh SinghDepartment of Bioengineering, College of Engineering and Computing, George Mason University, Fairfax, Virginia 22030, United States.ORCID 0000-0002-2874-4971
Liszt Y C MadrugaDepartment of Bioengineering, College of Engineering and Computing, George Mason University, Fairfax, Virginia 22030, United States.ORCID 0000-0002-2002-7644
Aniruddha SavargaonkarDepartment of Mechanical Engineering, Colorado State University, Fort Collins, Colorado 80523, United States.ORCID 0009-0005-2680-2233
Alessandro F MartinsDepartment of Chemical and Biological Engineering, Colorado State University, Fort Collins, Colorado 80523, United States.ORCID 0000-0003-1002-3436
Matt J KipperDepartment of Chemical and Biological Engineering, Colorado State University, Fort Collins, Colorado 80523, United States.ORCID 0000-0002-8818-745X
Ketul C PopatDepartment of Bioengineering, College of Engineering and Computing, George Mason University, Fairfax, Virginia 22030, United States.ORCID 0000-0002-2417-7789

Funding

Nanostructured Surfaces With Improved HemocompatibilityR21EB033511 · NIBIB · GEORGE MASON UNIVERSITY · PI KIPPER, MATTHEW, POPAT, KETUL CHANDRAKANT · 2022 to 2023
$410k
NIBIB NIH HHS R21 EB033511
6 · The paper itself

Abstract

This study explores the synergistic effects of combining titania nanotubes (TiNTs) with the biopolymer Tanfloc (TAN) to enhance the surface properties of TiNTs for biomedical applications. We investigated the interactions of blood components and human adipose-derived stem cells (ADSCs) with TiNT surfaces covalently functionalized with Tanfloc (TAN), an aminolyzed polyphenolic tannin derivative. The functionalized surfaces (TiNT-TAN) have great potential to control protein adsorption and platelet adhesion and activation. Fluorescence and scanning electron microscopy (SEM) were used to analyze platelet adherence and activation. The amphoteric nature and multiple functional groups on TAN can control blood protein adsorption, platelet adhesion, and activation. Further, the modified surface supports adipose-derived stem cell (ADSC) viability, attachment, and growth without any cytotoxic effect. The TAN conjugation significantly (****

Indexed as

Biocompatible MaterialsBlood CoagulationStem CellsTitaniumAdipose TissueAdsorptionCell AdhesionCell ProliferationCells, CulturedCell SurvivalHumansNanotubesPlatelet AdhesivenessSurface PropertiesBiocompatible MaterialsTitaniumtitanium dioxidemedical implantsplatelet activationprotein adsorptionsurface functionalizationtitania nanotube

Identifiers

PMID40013664
PMCPMC11897940

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.