Evidence map›Paper›PMID 40013626›Full record

ArticleLung India : official organ of Indian Chest Society2025

Improvement in radiologic findings over time is associated with increased survival in patients with viral ARDS requiring extracorporeal membrane oxygenation.

Laura DiChiacchio, Ikeoluwapo Ibrahim, Alison Grazioli, Neda Bionghi, Kiran Batra, Sameer Chabbra, Nicholas Ladikos, Vaidehi Kaza, Srinivas Bollineni, Manish R Mohanka and 5 more

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Article in Lung India : official organ of Indian Chest Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Laura DiChiacchioDepartment of Cardiothoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Ikeoluwapo IbrahimDepartment of Anesthesiology, Yale New Haven Hospital, New Haven, Connecticut, USA.
Alison GrazioliDepartment of Nephrology, University of Maryland Medical System, Baltimore, Maryland, USA.
Neda BionghiDivision of Pulmonology and Critical Care, UT Southwestern Medical Center, Dallas, Texas, USA.
Kiran BatraDivision of Cardiothoracic Imaging, UT Southwestern Medical Center, Dallas, Texas, USA.
Sameer ChabbraMedical Student, Medical College of Wisconsin, Wauwatosa, Wisconsin, USA.
Nicholas LadikosDepartment of Pharmacy, Texas Tech University Health Sciences Center, Dallas, Texas, USA.
Vaidehi KazaDivision of Pulmonology and Critical Care, UT Southwestern Medical Center, Dallas, Texas, USA.
Srinivas BollineniDivision of Pulmonology and Critical Care, UT Southwestern Medical Center, Dallas, Texas, USA.
Manish R MohankaDepartment of Pulmonary Disease and Critical Care Medicine, Northwell Health Physician Partners, Manhasset, New York, USA.
Adrian LawrenceDivision of Pulmonology and Critical Care, UT Southwestern Medical Center, Dallas, Texas, USA.
Fernando TorresDivision of Pulmonology and Critical Care, UT Southwestern Medical Center, Dallas, Texas, USA.
Aldo IaconoDepartment of Pulmonary Disease and Critical Care Medicine, Northwell Health Physician Partners, Manhasset, New York, USA.
Daniel HerrDepartment of Critical Care, Medical University of South Carolina, Charleston, South Carolina, USA.
Irina TimofteDivision of Pulmonology and Critical Care, UT Southwestern Medical Center, Dallas, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAcute respiratory distress syndrome (ARDS) requiring venovenous extracorporeal membrane oxygenation (VV ECMO) support is associated with chest radiograph changes commonly referred to as "drowning ECMO lung" ECMO lung presents as white-out of both lung fields, involving all lobes of the bilateral lungs. While the clinical significance of chest radiograph findings over time has been described in the general ARDS population, it has not been evaluated specifically in VV ECMO patients. This subpopulation suffers the most severe disease as well as the confounding effects of ECMO support. MATERIALS AND

methodsWe identified 28 patients requiring VV ECMO cannulation for influenza-related ARDS between September 2009 and January 2018. Interpretation of chest X-ray images was divided into zones that correspond to anatomical lobes on computed tomography. Progression of radiologic injury was assessed by analysing the number of zones involved on the chest radiograph (X-ray) at days 1, 3, 7, 14, and 21 from cannulation and discharge. The primary endpoint was survival to hospital discharge.

resultsThe majority of patients had complete opacification on days 1, 3, and 7 after VV ECMO cannulation. Patients with persistent complete opacification on chest X-ray infiltrate by day 14, following cannulation had an increased mortality. Survival to hospital discharge was increased in patients demonstrating improvement in radiological findings at day 19 compared to patients without significant radiologic improvement (100% vs 53%, log-rank P = 0.003).

conclusionThe evolution and recovery of lung injury reflected by serial chest X-ray imaging studies after influenza-related ARDS requiring VV ECMO support is associated with improved survival in this single centre, retrospective cohort.

Identifiers

PMID40013626
PMCPMC11952723

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.