Evidence map›Paper›PMID 40013582›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2025

Design and synthesis of novel HDAC6 inhibitor dimer as HDAC6 degrader for cancer treatment by palladium catalysed dimerisation.

Ching Lin, Jui-Ling Hsu, Yu-Tung Hsu, Kuo-Chen Fan, Sian-Siou Wu, Miao-Hsia Lin, Jih-Hwa Guh, Chao-Wu Yu

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ching LinSchool of Pharmacy, National Taiwan University, Taipei, ROC.ORCID 0009-0003-4077-8271
Jui-Ling HsuSchool of Pharmacy, National Taiwan University, Taipei, ROC.
Yu-Tung HsuSchool of Pharmacy, National Taiwan University, Taipei, ROC.
Kuo-Chen FanSchool of Pharmacy, National Taiwan University, Taipei, ROC.
Sian-Siou WuSchool of Pharmacy, National Taiwan University, Taipei, ROC.
Miao-Hsia LinDepartment and Graduate Institute of Medical Microbiology, College of Medicine, National Taiwan University, Taipei, ROC.
Jih-Hwa GuhSchool of Pharmacy, National Taiwan University, Taipei, ROC.
Chao-Wu YuSchool of Pharmacy, National Taiwan University, Taipei, ROC.ORCID 0000-0002-5176-4225

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The enigmatic histone deacetylase 6 (HDAC6) is one of a kind among its family. Recent reports revealed that HDAC6 CD1 exhibits E3 ligase activity. Inspired by these researches, we attempted to develop drugs targeting HDAC6

Indexed as

Antineoplastic AgentsDrug DesignHistone Deacetylase 6Histone Deacetylase InhibitorsHydroxamic AcidsPalladiumApoptosisCatalysisCell Line, TumorCell ProliferationDimerizationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsHDAC6 protein, humanHistone Deacetylase 6Histone Deacetylase InhibitorsHydroxamic AcidsPalladiumanticancercouplingHDAC6palladiumprotein degrader

Identifiers

PMID40013582
PMCPMC11869342

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.