ArticleJournal of cosmetic dermatology2025
Causal Association Between Inflammatory Factors and Hypertrophic Scar: A Two-Sample Mendelian Randomization Study.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertrophic scars result from abnormal healing following skin injuries.
aimTo delve deeper into the causal association between inflammatory factors and hypertrophic scars.
methodsThis study utilized genetic data from the FINN cohort and pertinent literature to scrutinize the nexus between a spectrum of inflammatory factors-encompassing IL-1β, interleukin 1 receptor-like 1, MCP1, RANTES/CCL5, TNFα, IL-8, IL-18, and CTACK/CCL27-and the risk of hypertrophic scarring. Our analytical strategy was based on the inverse variance weighted (IVW) approach, further bolstered by MR-Egger, weighted median, and weighted mode methods to ensure a comprehensive assessment. The reliability of our findings was rigorously appraised through Cochran's Q test, MR-Egger regression, MR-PRESSO, and leave-one-out analysis.
resultsThe genetic prediction results revealed a significant association between CTACK and hypertrophic scars (OR 1.21, 95% CI 1.05-1.4, p = 0.01) using the IVW method, although it was not corroborated by other MR analysis methods. The remaining inflammatory factors did not exhibit significant correlations with the risk of hypertrophic scar formation (all p > 0.05). The absence of significant heterogeneity among the IVs was indicated by Cochran's Q test. MR-Egger and MR-PRESSO analyses collectively suggested no substantial horizontal pleiotropy influencing the results, except for the relationship between RANTES and hypertrophic scars. Upon exclusion of an outlier, the causal relationship between RANTES and hypertrophic scars was found to be non-significant.
conclusionOur MR analysis supports a causal association between CTACK and hypertrophic scars, enhancing our understanding of scar formation and suggesting potential targeted therapeutic strategies for treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.