Evidence map›Paper›PMID 40013455›Full record

ArticleSynapse (New York, N.Y.)2025

Cellular-Resolution and Bulk-Fluorescence Recordings of Calcium Activity Yield Reciprocal Readouts of In Vivo Drug Efficacy.

Seongsik Yun, Jones G Parker

Abstract read
In one paragraph

Article in Synapse (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Seongsik YunDepartment of Neuroscience, Northwestern University, Chicago, Illinois, USA.
Jones G ParkerDepartment of Neuroscience, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0001-9302-1545

Funding

Dopamine, Synaptic Plasticity and Striatal Ensemble Dynamics Underlying Motor LearningR01NS122840 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PARKER, JONES G · 2021 to 2025
$2.2M
Optical Dissection of the Neural Circuitry Controlling Sensorimotor GatingK01MH113132 · NIMH · STANFORD UNIVERSITY · PI PARKER, JONES G · 2017 to 2020
$589k
NIMH NIH HHS K01 MH113132NINDS NIH HHS R01 NS122840
6 · The paper itself

Abstract

Genetically encoded fluorescent sensors of neural activity have become a mainstay of basic neuroscience. However, preclinical drug development has been slower to adopt these tools. Recently, we used miniature microscopes to record Ca

Indexed as

Antipsychotic AgentsCalciumNeuronsAmphetamineAnimalsMaleMiceReceptors, Dopamine D1Receptors, Dopamine D2AmphetamineAntipsychotic AgentsCalciumReceptors, Dopamine D1Receptors, Dopamine D2

Identifiers

PMID40013455
PMCPMC11866263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.