Evidence map›Paper›PMID 40013430›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2025

Association Between Prenatal Antibiotic Exposure and Infant Wheeze Outcomes.

Rachel G Greenberg, Amii M Kress, Guojing Wu, J Wells Logan, Cindy T McEvoy, Frank Gilliland, Judy Aschner, Kecia N Carroll, Maria M Talavera-Barber, Margaret R Karagas and 4 more

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In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Rachel G GreenbergDuke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-4156-8543
Amii M KressJohns Hopkins University, Baltimore, Maryland, USA.
Guojing WuJohns Hopkins University, Baltimore, Maryland, USA.
J Wells LoganUniversity of Florida College of Medicine, Jacksonville, Florida, USA.
Cindy T McEvoyOregon Health & Science University, Portland, Oregon, USA.
Frank GillilandUniversity of Southern California, Los Angeles, California, USA.
Judy AschnerHackensack Meridian School of Medicine, Nutley, New Jersey, USA.
Kecia N CarrollIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Maria M Talavera-BarberAvera Research Institute, Sioux Falls, South Dakota, USA.
Margaret R KaragasGeisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Maria José RosaIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Joanne SordilloHarvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
P Brian SmithDuke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
program collaborators for Environmental influences on Child Health Outcomes

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Phillip Brian Smith · 2016 to 2026
$215.9M
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUH3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2018 to 2026
$64.8M
Mount Sinai ECHO site for Perinatal Environment and Development StudiesUH3OD023337 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2018 to 2026
$54.1M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3M
The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7M
Environmental Influences on Childhood Outcomes in the Northern Plains Safe Passage Study CohortsUH3OD023279 · OD · AVERA MCKENNAN · PI Amy J Elliott, Christine W Hockett · 2018 to 2026
$31.7M
Understanding Breastfeeding Practices Among ECHO Cohort Participants Before and During/After the COVID-19 PandemicUH3OD023285 · OD · MICHIGAN STATE UNIVERSITY · PI Charles James Barone, MICHAEL R. ELLIOTT · 2018 to 2026
$24.5M
The Developing Brain: Influences and OutcomesUH3OD023313 · OD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI Viren Andrew D'Sa, Daphne Koinis Mitchell · 2018 to 2026
$20.7M
BREAKING THE CYCLE OF INTERGENERATIONAL DISADVANTAGE: NEURODEVELOPMENT AMONG PUERTO RICAN CHILDREN.UH3OD023328 · OD · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI CANINO, GLORISA J, DUARTE, CRISTIANE S. · 2018 to 2022
$18.3M
Environmental Influences on Child Health Outcomes in the Northern Plains Safe Passage Study CohortUG3OD023279 · OD · SANFORD RESEARCH/USD · PI ELLIOTT, AMY J, HOCKETT, CHRISTINE W · 2016 to 2024
$17.5M
NCATS NIH HHS UL1 TR004419NHLBI NIH HHS R01 HL159701NIAID NIH HHS U24 AI179612NIH HHS U24 OD023319NIH HHS U24 OD023382NIH HHS U2C OD023375NIH HHS UG3 OD023279NIH HHS UH3 OD023275NIH HHS UH3 OD023279NIH HHS UH3 OD023282NIH HHS UH3 OD023285NIH HHS UH3 OD023286NIH HHS UH3 OD023313NIH HHS UH3 OD023320NIH HHS UH3 OD023328NIH HHS UH3 OD023337NIH Office of the Director U24OD023319NIH Office of the Director U24OD023382NIH Office of the Director U2COD023375NIH Office of the Director UH3OD023275NIH Office of the Director UH3OD023279NIH Office of the Director UH3OD023282NIH Office of the Director UH3OD023285NIH Office of the Director UH3OD023286NIH Office of the Director UH3OD023313NIH Office of the Director UH3OD023320NIH Office of the Director UH3OD023328NIH Office of the Director UH3OD023337Office of Behavioral and Social Sciences Research
6 · The paper itself

Abstract

aimThis study examined the association between antibiotic exposure during pregnancy and the development of wheezing and cough during infancy.

methodsWe analysed data from 12 cohorts in the Environmental influences on Child Health Outcomes Cohort Consortium. Outcomes during the first 18 months after birth included the presence of wheeze or dry cough and treatment or intervention for these symptoms, including medications, emergency room visits, and hospitalisations. We used generalised estimating equations and logistic models with adjustment for inverse propensity scores for exposure to antibiotics.

resultsA total of 4721 pregnancies were included, resulting in 4779 infants. Overall, 1,701/4,721 (36%) individuals received antibiotics during pregnancy, and wheezing was reported in 1,214/4,779 (26%) infants. In adjusted analyses, prenatal antibiotics were not associated with a higher odds of wheeze (OR = 1.06; 95% CI 0.91, 1.24) or hospitalisations or emergency room visits for wheeze or dry cough. However, prenatal antibiotic exposure was associated with a higher odds of medication use for wheeze or dry cough (OR = 1.62; 95% CI 1.10, 2.38).

conclusionsPrenatal antibiotic exposure may be associated with an increased odds of medication use for wheeze or dry cough during infancy but may not increase the risk of more severe events.

Indexed as

Anti-Bacterial AgentsCoughPrenatal Exposure Delayed EffectsRespiratory SoundsCohort StudiesFemaleHumansInfantInfant, NewbornMalePregnancyAnti-Bacterial Agentsanti‐bacterial agentschildreninfantspregnancywheezing

Identifiers

PMID40013430
PMCPMC12259374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.