Trial reportJournal of cosmetic dermatology2025
A Randomized Double-Blind Controlled Evaluation of the Therapeutic Benefits of an Herbal Lip Hydrant.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06475482 (Development of a Novel Polyherbal Lip Hydrant for Improving Biophysical Barrier of the Lips), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of a Novel Polyherbal Lip Hydrant for Improving Biophysical Barrier of the Lips
Who cites it
1 citing paper in PubMed.
- Aging of the Human Lip: Current Knowledge and Clinical Implications.Journal of cosmetic dermatology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveDry and chapped lips adversely affect both lip structure and function, yet there is no established gold standard for their treatment. Herbal extracts present a promising alternative due to their natural properties, though their therapeutic potential for lip care remains underexplored. This study aims to develop and clinically evaluate a novel lip hydrant formulated with polyherbal extracts, with the objective of offering an effective solution for managing dry and chapped lips.
methodsSix herbal extracts and eight mixtures, consisting of at least three herbal extracts, were evaluated for cytotoxicity using the MTT assay in HaCaT cells. The essential molecular markers were examined by western blot analysis and immunofluorescence assay. The selected mixture was formulated into lip hydrant and tested in a randomized, double-blind, controlled clinical trial. The 66 Thai participants with dry lip concerns were randomly assigned into two groups. Each participant applied either the lip hydrant (test group) or petroleum gel (control group) once daily for 28 days. Clinical assessments were performed at baseline and on day 28 post-application. The lip conditions, lip texture wrinkles, and hemoglobin levels were measured. Participant assessments included ratings of lip dryness, appearance, and product satisfaction.
resultsThe herbal extracts demonstrated potential in strengthening cell adherence, providing antioxidant effect, and inducing self-renewal. The Mix2 shows the most promising activity, increasing adherent protein and stemness properties, and was selected as the active ingredient for the clinical trial. In the trial, both the test and control groups experienced a significant reduction in lip roughness by day 28 compared to baseline (p < 0.05). However, the test group exhibited a significantly greater reduction in chapped lips than the control group (p < 0.05). No significant differences were found between the groups in terms of lip texture, wrinkle levels, or hemoglobin levels. Notably, both groups showed significant improvements in perceived lip dryness by day 28 (p < 0.001).
conclusionThe study findings support the therapeutic potential of the novel polyherbal lip hydrant in improving lip hydration, reducing roughness, and alleviating chapped lips (ClinicalTrials.gov ID: NCT06475482).
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