ArticleJournal Of Elasticity2025
Cell-Level Modelling of Homeostasis in Confined Epithelial Monolayers.
Article in Journal Of Elasticity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Mitotic shape changes drive spatiotemporally segregated cell-contact rearrangements in a proliferating epithelium.Current biology : CB · 2026Article
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4 authors.
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Abstract
Tissue homeostasis, the biological process of maintaining a steady state in tissue via control of cell proliferation and death, is essential for the development, growth, maintenance, and proper function of living organisms. Disruptions to this process can lead to serious diseases and even death. In this study, we use the vertex model for the cell-level description of tissue mechanics to investigate the impact of the tissue environment and local mechanical properties of cells on homeostasis in confined epithelial tissues. We find a dynamic steady state, where the balance between cell divisions and removals sustains homeostasis, and characterise the homeostatic state in terms of cell count, tissue area, homeostatic pressure, and the cells' neighbour count distribution. This work, therefore, sheds light on the mechanisms underlying tissue homeostasis and highlights the importance of mechanics in its control.
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