ArticleCureus2025
Hickam's Dictum Prevails: Kaposi Sarcoma and Primary Effusion Lymphoma in a Person Living With Human Immunodeficiency Virus (HIV) and Human Herpesvirus 8 (HHV-8) Infection.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- HIV-driven tumor ecosystem: from chronic immune dysfunction to cancer evolution.Frontiers in microbiology · 2026Review
- Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human immunodeficiency virus (HIV) infection has a plethora of effects on its host, including increased susceptibility to opportunistic infections and increased likelihood of developing HIV-associated malignancies. The combined cellular dysfunction orchestrated by co-infection with oncogenic viruses, such as human herpesvirus-8 (HHV-8) and Epstein-Barr virus (EBV), further amplifies the risk of malignancy in people living with HIV/AIDS (PLHA). We report a rare case of Kaposi sarcoma (KS) and extra cavitary primary effusion lymphoma (EPEL) in a 48-year-old woman with advanced HIV disease on antiretroviral treatment presenting with arthralgia, generalized body weakness, drenching night sweats, cavitary effusions, a violaceous rash on her left leg, as well as generalized lymphadenopathy. This report highlights the shared etiological role of HHV-8 in PLHA with both KS and EPEL. Given the rarity of the dual presentation of these conditions, it shows that the prudent application of Occam's razor may suffice in the majority of cases. However, Hickam's dictum should be applied when such diagnostic dilemmas exist.
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