ArticleCureus2025
Lactulose-Induced Pneumatosis Intestinalis Causing Sudden Deterioration in a Patient With Advanced Hepatic Disease.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Herein, we present a case of a 53-year-old male who developed pneumatosis intestinalis (PI) while being treated for hepatic encephalopathy with lactulose. Initially, the patient was administered lactulose, the standard treatment for lowering ammonia levels associated with hepatic encephalopathy; however, this approach unexpectedly resulted in the acute onset of severe PI, which persisted even after lactulose was stopped, further compromising the patient's health. Despite intensive management and the cessation of lactulose, the patient's condition rapidly declined, leading to a transition to palliative care and eventual death. Comparative studies have indicated that both PI and pneumoperitoneum can be triggered by lactulose therapy, with symptoms reversing upon the discontinuation of the medication. This case raises significant concerns regarding the use of lactulose in patients suffering from advanced hepatic disease and multiple comorbidities.
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