ReviewCureus2025
Strategies for Overcoming Bacterial Resistance to Nanoparticles: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Biogenic Metal Nanoparticles from Indian Flora as Programmable Bio-Interfaces: From Phytochemical Coronas to Precision Nanomedicine.International journal of molecular sciences · 2026Review
- Functionalized polysaccharides for infection-resistant and regenerative therapies in gynecology.International journal of pharmaceutics: X · 2026Review
- Natural Products and Antimicrobial Nanoparticles Against Methicillin-ResistantPharmaceutics · 2026Review
- Biogenic copper and copper oxide nanoparticles to combat multidrug-resistantBiotechnology reports (Amsterdam, Netherlands) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing prevalence of bacterial resistance to conventional antimicrobial agents and nanoparticles (NPs) has become a critical global health challenge. This systematic review aimed to evaluate strategies for overcoming bacterial resistance to nanoparticles by synthesizing evidence on nanoparticle composition, functionalization, and targeted resistance mechanisms. A comprehensive literature search of studies published between 2000 and 2025 was conducted, focusing on experimental designs assessing antimicrobial efficacy, biofilm disruption, and efflux pump inhibition. The reviewed studies highlighted advanced nanoparticle formulations, including silver-cyanographene conjugates, lanthanum-functionalized graphene oxide, and carbon nanogels, which demonstrated enhanced efficacy against resistant bacterial strains. Key findings emphasized the role of surface functionalization, nanoparticle size modulation, and combination therapies in mitigating resistance. Functionalized nanoparticles effectively disrupted biofilm matrices, inhibited efflux pumps, and enhanced intracellular penetration, reducing bacterial survival rates. Despite promising results, challenges remain, including variability in nanoparticle formulations, limited scalability, and long-term ecological impacts. This review underscores the potential of innovative nanoparticle designs and combination therapies to combat bacterial resistance and emphasizes the need for standardized protocols and clinical translation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.