Evidence map›Paper›PMID 40013145›Full record

ArticleFrontiers in immunology2025

Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency.

Jungnam Lee, Naweed Mohammad, Kyudong Han, Tammy Flagg-Dowie, Maria Magallon, Mark L Brantly, Karina A Serban

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Monocyte-mediated mechanisms in idiopathic pulmonary fibrosis: opportunities for early intervention.Apoptosis : an international journal on programmed cell death · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jungnam LeeDivision of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, United States.
Naweed MohammadDivision of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, United States.
Kyudong HanDepartment of Microbiology, College of Bio-convergence, Dankook University, Cheonan, Republic of Korea.
Tammy Flagg-DowieDivision of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, United States.
Maria MagallonDivision of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, United States.
Mark L BrantlyDivision of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, United States.
Karina A SerbanDivision of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, United States.

Funding

Decay accelerating factor (CD55) protects against lectin pathway-mediated AT2 cell dysfunction in cigarette smoke-induced emphysemaR01HL166828 · NHLBI · UNIVERSITY OF FLORIDA · PI Karina Serban · 2023 to 2026
$2.8M
NHLBI NIH HHS R01 HL166828
6 · The paper itself

Abstract

Neutrophilic inflammation and a high level of free α-defensins are main features of chronic airway inflammation in alpha-1 antitrypsin-deficient (AATD) individuals. Despite the antimicrobial activities of α-defensins by direct bacterial killing and by modulation of immune responses, AATD individuals are paradoxically burdened by recurrent exacerbation triggered by bacterial infections, frequently with nontypeable

Indexed as

alpha 1-Antitrypsin Deficiencyalpha-DefensinsHaemophilus InfectionsHaemophilus influenzaeMacrophagesMacrophages, AlveolarPhagocytosisAdultCytokinesFemaleHumansInflammationMaleMiddle AgedToll-Like Receptor 4alpha-DefensinsCytokinesToll-Like Receptor 4AAT deficiency (AATD)alpha 1 antitrypsin (AAT)alpha defensinscytokinesmacrophagesneutrophilsphagocytosis

Identifiers

PMID40013145
PMCPMC11861504

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.