Evidence map›Paper›PMID 40013081›Full record

ArticleToxicological research2025

Alleviating doxorubicin-induced reproductive toxicity: protective and androgenic effects of drone larvae on sperm morphology and hormonal balance.

Kağan Ağan, Salih Tunç Kaya, Aydan Fülden Ağan, Pınar Ağyar-Yoldaş, Taner Yoldaş, Ayşe İkinci-Keleş, Tuğçe Çaprazlı, Elif Arıca, Meral Kekeçoglu

Abstract read
In one paragraph

Article in Toxicological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Investigation of the Protective Effect ofInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kağan AğanExperimental Animals Application and Research Center, Düzce University, Düzce, Türkiye.ORCID 0000-0003-1472-570X
Salih Tunç KayaDepartment of Biology, Faculty of Arts and Science, Düzce University, Düzce, Türkiye.ORCID 0000-0002-4133-407X
Aydan Fülden AğanExperimental Animals Application and Research Center, Düzce University, Düzce, Türkiye.ORCID 0000-0002-4319-6264
Pınar Ağyar-YoldaşThe Scientific and Technological Research Application and Research Center, Düzce University, Düzce, Türkiye.ORCID 0000-0002-9277-0648
Taner YoldaşThe Scientific and Technological Research Application and Research Center, Düzce University, Düzce, Türkiye.ORCID 0000-0002-0209-312X
Ayşe İkinci-KeleşDepartment of Histology and Embryology, Faculty of Medicine, Aksaray University, Aksaray, Türkiye.ORCID 0000-0003-0716-5695
Tuğçe ÇaprazlıDepartment of Plant and Animal Production, Düzce Vocational School, Beekeeping Programme, Düzce University, Düzce, Türkiye.ORCID 0000-0001-9109-0969
Elif ArıcaCentro Laboratuvarlari, Kagithane, Istanbul, Türkiye.ORCID 0009-0009-7519-4069
Meral KekeçogluDepartment of Biology, Faculty of Arts and Science, Düzce University, Düzce, Türkiye.ORCID 0000-0002-2564-8343

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Male infertility and compromised sperm quality are common side effects of Doxorubicin (DOX), a widely used chemotherapy drug. Its detrimental impact on male reproductive cells underscores the urgent need for effective protective measures. Lyophilized drone larvae (DL) from apitherapy have emerged as a potential solution due to their reported protective properties. By exploring DL's therapeutic potential, this research seeks to address the pressing need for strategies to protect male reproductive health during cancer treatment. The study aims to evaluate the protective effects of lyophilized DL from apitherapy against DOX-induced testicular damage in adult

Indexed as

ApilarnilDoxorubicinDrone LarvaeMale infertilityReproductive healthTesticular damage

Identifiers

PMID40013081
PMCPMC11850692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.