Evidence map›Paper›PMID 40013019›Full record

ArticleERJ open research2025

Low-grade systemic inflammation and peripheral airway function.

Martin Färdig, Suneela Zaigham, Gunnar Engström, Christer Janson, Per Wollmer, Andrei Malinovschi

Abstract read
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Martin FärdigDepartment of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0003-2274-752X
Suneela ZaighamDepartment of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.
Gunnar EngströmDepartment of Clinical Sciences, Cardiovascular Epidemiology, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0002-8618-9152
Christer JansonDepartment of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0001-5093-6980
Per WollmerDepartment of Translational Medicine, Clinical Physiology and Nuclear Medicine, Lund University, Lund, Sweden.
Andrei MalinovschiDepartment of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0002-4098-7765

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Low-grade systemic inflammation is linked to abnormal spirometry. Impulse oscillometry (IOS) is sensitive in detecting peripheral airway dysfunction, but inflammation in relation to IOS is poorly studied. The objectives of the present study were to analyse associations between C-reactive protein (CRP), blood eosinophils (B-Eos), blood neutrophils (B-Neu), blood lymphocytes (B-Lym), blood leukocytes (B-Leu), blood monocytes (B-Mono) and IOS. Methods: Blood biomarkers and IOS were assessed in 10 602 adults (aged 50-65 years) within the Swedish CardioPulmonary bioImage Study (SCAPIS). Upper tertiles for CRP (>1.80 mg·L Results: Abnormal IOS was observed in 1715 (16.2%), of which 580 (33.8%) also had abnormal spirometry. Having several blood biomarkers in the upper tertile (1, 2-3 or 4-6 Conclusions: Low-grade systemic inflammation was related to abnormal IOS and appeared consistent even when participants had normal spirometry.

Identifiers

PMID40013019
PMCPMC11864351

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.