Evidence map›Paper›PMID 40012870›Full record

ArticleEnvironment & health (Washington, D.C.)2025

Non-Targeted Analysis of Environmental Contaminants and Their Associations with Semen Health Factors in Men from New York City.

Trevor A Johnson, Sarah Adelman, Bobby B Najari, Joshua F Robinson, Linda G Kahn, Dimitri Abrahamsson

Abstract read
In one paragraph

Article in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. New Pollutants Study: Challenges and Prospects.Environment & health (Washington, D.C.) · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Trevor A JohnsonNew York University, Grossman School of Medicine, Department of Pediatrics, New York, New York 10016, United States.ORCID https://orcid.org/0000-0001-7957-5859
Sarah AdelmanNew York University, Grossman School of Medicine, Department of Pediatrics, New York, New York 10016, United States.
Bobby B NajariNew York University, Grossman School of Medicine, Department of Urology, New York, New York 10016, United States.
Joshua F RobinsonUniversity of California San Francisco, Department of Obstetrics, Gynecology, and Reproductive Sciences, San Francisco, California 94143, United States.
Linda G KahnNew York University, Grossman School of Medicine, Department of Pediatrics, New York, New York 10016, United States.
Dimitri AbrahamssonNew York University, Grossman School of Medicine, Department of Pediatrics, New York, New York 10016, United States.

Funding

UCSF Environmental Research and Translation for Health Center (EaRTH Center)P30ES030284 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Peggy Reynolds · 2020 to 2026
$11.2M
Nonpersistent chemical exposure, placental development, and maternal pre- and post-pregnancy cardiovascular healthR00ES030403 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KAHN, LINDA G · 2022 to 2024
$746k
Non-target analysis of maternal and cord blood samples: Advancing computational tools and discovering novel chemicalsR00ES032892 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABRAHAMSSON, DIMITRI · 2023 to 2025
$745k
Nonpersistent chemical exposure, placental development, and maternal pre- and post-pregnancy cardiovascular healthK99ES030403 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KAHN, LINDA G · 2019 to 2020
$220k
Non-target analysis of maternal and cord blood samples: Advancing computational tools and discovering novel chemicalsK99ES032892 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABRAHAMSSON, DIMITRI · 2021 to 2022
$200k
NIEHS NIH HHS K99 ES030403NIEHS NIH HHS K99 ES032892NIEHS NIH HHS P30 ES030284NIEHS NIH HHS R00 ES030403NIEHS NIH HHS R00 ES032892
6 · The paper itself

Abstract

Characterizing the chemical composition of semen can provide valuable insights into the exposome and environmental factors that directly affect seminal and overall health. In this study, we compared molecular profiles of 45 donated semen samples from general population New York City participants and examined the correlation between the chemical profiles in semen and fertility parameters, i.e., sperm concentration, sperm motility, sperm morphology, and semen volume. Samples were prepared using a protein precipitation procedure and analyzed using liquid chromatography (LC) coupled to high-resolution mass spectrometry (HRMS). Non-targeted analysis (NTA) revealed 18 chemicals not previously reported in human exposome studies, with 3-hydroxyoctanedioic acid, a cosmetic additive, emerging as a plausible candidate found to be at higher levels in cases vs controls (

Identifiers

PMID40012870
PMCPMC11851215

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.