Evidence map›Paper›PMID 40012807›Full record

ArticleJournal of current ophthalmology

Investigation of the Neuroprotective Effect of Riluzole on Matrix Metalloproteinases in an Experimental Model of Glaucoma.

Fatma Yildiz, Nedime Sahinoglu-Keskek, Işıl Tan Yilmaz, İbrahim Aydin Candan, Orhan Tansel Korkmaz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of current ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fatma YildizDepartment of Medical Laboratory Techniques, Health Services Vocational School, Alanya Alaaddin Keykubat University, Alanya, Turkey.
Nedime Sahinoglu-KeskekDepartment of Ophthalmology, Faculty of Medicine, Alanya Alaaddin Keykubat University, Alanya, Turkey.
Işıl Tan YilmazDepartment of Anesthesia, Ataturk Health Services Vocational School, Dicle University, Diyarbakır, Turkey.
İbrahim Aydin CandanDepartment of Histology and Embryology, Faculty of Medicine, Alanya Alaaddin Keykubat University, Alanya, Turkey.
Orhan Tansel KorkmazDepartment of Physiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate the neuroprotective effect of riluzole through matrix metalloproteinase-2 (MMP-2) and MMP-9 in rats, in an experimental glaucoma model. Methods: A total of 28 Results: As a result, a statistically significant increase in intraocular pressures (IOP) was found in Groups II, III, and IV when compared with the control eyes after 7 weeks ( Conclusions: MMP-2 and MMP-9 exhibited decreased expression levels in both Group III (glaucoma + corn oil + DMSO) and Group IV (glaucoma + corn oil + DMSO + 5 mg/kg riluzole) compared to the glaucoma groups in Group II. Given that both Group III and Group IV received injections of corn oil + DMSO, this conclusion was drawn.

Indexed as

GlaucomaIntraocular pressureMatrix metalloproteinase-2Matrix metalloproteinase-9NeuroprotectionRiluzole

Identifiers

PMID40012807
PMCPMC11856119

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.